AKT1 E17K mutant is phosphorylated by TORC2 complex

Stable Identifier
R-HSA-2243938
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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AKT1 E17K mutant is phosphorylated by TORC2 complex
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PIP2-binding AKT1 E17K mutants are anchored to the plasma membrane in the absence of PI3K activity and are constitutively phosphorylated on serine S473, presumably by the TORC2 complex (Carpten et al. 2007, Landgraf et al. 2008).
Literature References
PubMed ID Title Journal Year
18954143 Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain

Falke, JJ, Landgraf, KE, Pilling, C

Biochemistry 2008
17611497 A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Tucker-Kellogg, G, Lin, A, Blanchard, KL, Carpten, JD, Qian, YW, Moses, TY, Briggs, SL, Zeckner, DJ, Hostetter, G, Bittner, M, Savage, S, Thomas, JE, Uhlik, M, Du, J, Boguslawski, S, Robbins, CM, Schevitz, R, Touchman, J, Patel, K, Mousses, S, Lai, MHT, Faber, AL, Donoho, GP, Horn, C

Nature 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of TORC2 complex [cytosol]

Physical Entity
TORC2 complex [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Functional status

Gain of function of AKT1 E17K mutant:PIP2 [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Orlic-Milacic, M  (2012-05-09)
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