Reactome | Me3K5-HIST3H3 [nucleoplasm]

Me3K5-HIST3H3 [nucleoplasm]

Stable Identifier

R-HSA-2245188

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H3.4 K4me3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Me3K5-HIST3H3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16695 H3-4

Gene Names

H3-4, H3FT, HIST3H3

Chain

initiator methionine:, chain:2-136

Reference Genes

BioGPS Gene:8290 H3-4

CTD Gene:8290 H3-4

dbSNP Gene:8290 H3-4

ENSEMBL:ENSG00000168148 HIST3H3

ENSEMBL_homo_sapiens_GENE:ENSG00000168148.4 H3-4

ENSEMBL_homo_sapiens_GENE:ENSG00000285435.3 H3-4

HGNC:4778 H3-4

KEGG Gene (Homo sapiens):8290 H3-4

Monarch:8290 H3-4

NCBI Gene:8290 H3-4

OMIM:602820 H3-4

UCSC:Q16695 H3-4

Reference Transcript

RefSeq:NM_003493.2 H3-4

Other Identifiers

11734595_at

16700233

208572_PM_at

208572_at

2459606

2459607

7924884

8290

ADDON002893.hg

A_23_P137909

GE568338

GO:0000781

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0065003

GO:0070062

HMNXSV003053825

ILMN_1707173

PH_hs_0029513

TC01003915.hg

g4504298_3p_at

Participates

as a candidate of

H3K4me3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST3H3 [nucleoplasm]

Me2K5-HIST3H3 [nucleoplasm]

Inferred To

cnp1 [nucleoplasm] (Schizosaccharomyces pombe)

Me3K5-HIST1H3A [nucleoplasm] (Plasmodium falciparum)

H3a [nucleoplasm] (Dictyostelium discoideum)

Homologues of Me3K5-HIST1H3A [nucleoplasm] (Plasmodium falciparum)

H3f4 [nucleoplasm] (Mus musculus)

LOC100297725 [nucleoplasm] (Bos taurus)

CSE4 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 5

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_003484.1

OpenTargets

ENSG00000168148

GeneCards

Q16695

HPA

ENSG00000168148-H3-4

Ensembl

ENSG00000285435, ENST00000644869, ENSP00000494070, ENSG00000168148, ENSP00000355657, ENST00000366696

PRO

Q16695

Pharos - Targets

Q16695

PDB

6WAU, 2YBP, 3T6R, 6OIE, 4V2V, 6WAT, 3A6N, 2V1D, 4V2W, 2YBS

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.676	3
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.641	12
UniProt:O75164 KDM4A	2	K48PolyUb-KDM4A [nucleoplasm] (R-HSA-5683049) KDM4A [nucleoplasm] (R-HSA-351646)	0.618	6
UniProt:P04908 H2AC4	13	K63polyUb-HIST1H2AB [nucleoplasm] (R-HSA-6783287) Ub-HIST1H2AB [nucleoplasm] (R-HSA-6782483) Ack6-HIST1H2AB [nucleoplasm] (R-HSA-4568598) Me2aR30-HIST1H2AB [nucleoplasm] (R-HSA-5244538) MeR30-HIST1H2AB [nucleoplasm] (R-HSA-5244576) Me2aR4-HIST1H2AB [nucleoplasm] (R-HSA-5244628) MeR4-HIST1H2AB [nucleoplasm] (R-HSA-5244595) Me2sR4-HIST1H2AB [nucleoplasm] (R-HSA-5218304) Me2aR12-HIST1H2AB [nucleoplasm] (R-HSA-5229308) MeR12-HIST1H2AB [nucleoplasm] (R-HSA-5229221) HIST1H2AB [extracellular region] (R-HSA-977555) Ack-HIST1H2AB [nucleoplasm] (R-HSA-4551332) HIST1H2AB [nucleoplasm] (R-HSA-181888)	0.589	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.564	2
UniProt:Q9UHJ3 SMBT1			0.558	4
UniProt:Q0D2K3 RIPP1			0.556	3
UniProt:P49321-2 NASP			0.556	6
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.544	8