Interaction of DAP12 and KIR2DS5

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Killer cell immunoglobulin-like two-domain short-tail receptor 5 (KIR2DS5) is an activating KIR receptor expressed on natural killer (NK) cells and subpopulations of T lymphocytes (Nowak et al. 2010). KIR2DS5 has two Ig domains of the D1-D2 type, a short cytoplasmic tail and a positive charged transmembrane (TM) portion.
No physiological ligand has yet been identified for KIR2DS5 but it is able to associate with DAP12 and induce both cytotoxicity and cytokine release when KIR2DS5 is cross-linked with monoclonal antibody (Della Chiesa et al. 2008).
Literature References
PubMed ID Title Journal Year
18624290 Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function

Vitale, M, Falco, M, Moretta, A, Romeo, E, Balsamo, M, Bottino, C, Moretta, L, Augugliaro, R, Della Chiesa, M

Eur. J. Immunol. 2008
20865034 Does the KIR2DS5 gene protect from some human diseases?

Jankowska, R, Tchórzewski, H, Malinowski, A, Wilczyński, J, Kurpisz, M, Nowak, I, Wiland, P, Malejczyk, J, Płoski, R, Magott-Procelewska, M, Giebel, S, Kuśnierczyk, P, Gryboś, M, Chlebicki, A, Pawlik, A, Zoń-Giebel, A, Barcz, E, Łuszczek, W, Klinger, M, Passowicz-Muszyńska, E, Wiśniewski, A, Sun, JY, Majorczyk, E, Senitzer, D

PLoS ONE 2010
Orthologous Events
Cite Us!