PLK1 hyperphosphorylates Condensin II complex

Stable Identifier
R-HSA-2294580
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PLK1 hyperphosphorylates Condensin II complex
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Once PLK1 is recruited to the chromatin-bound condensin II complex, it phosphorylates the NCAPD3 subunit of condensin II on serine residue S1419, and possibly other residues. In addition to phosphorylating NCAPD3, PLK1 phosphorylates other condensin II subunits, NCAPG2 and NCAPH2. However, the phosphorylation sites have not yet been determined. PLK1-mediated phosphorylation of the condensin II complex facilitates condensation of prophase chromosomes (Abe et al. 2011).
Literature References
PubMed ID Title Journal Year
21498573 The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

Nagasaka, K, Hirota, T, Aoyagi, Y, Abe, S, Kozuka-Hata, H, Obuse, C, Oyama, M, Hirayama, Y

Genes Dev. 2011
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm]

Physical Entity
p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PLK1 hyperphosphorylates Condensin II complex (Bos taurus)
PLK1 hyperphosphorylates Condensin II complex (Caenorhabditis elegans)
PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)
PLK1 hyperphosphorylates Condensin II complex (Danio rerio)
PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)
PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)
PLK1 hyperphosphorylates Condensin II complex (Mus musculus)
PLK1 hyperphosphorylates Condensin II complex (Plasmodium falciparum)
PLK1 hyperphosphorylates Condensin II complex (Rattus norvegicus)
PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)
Authored
Orlic-Milacic, M  (2013-04-23)
Reviewed
Longworth, MS  (2013-10-14)
Created
Orlic-Milacic, M  (2012-05-31)
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