Reactome | PIP3 recruits PDPK1 to the membrane

PIP3 recruits PDPK1 to the membrane

Stable Identifier

R-HSA-2316429

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PIP3 recruits PDPK1 to the membrane (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated vascular permeability (Homo sapiens)
        
        PIP3 recruits PDPK1 to the membrane (Homo sapiens)

General

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PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9895304	Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Alessi, DR, Cohen, P, Downes, CP, Casamayor, A, Lucocq, J, Currie, RA, Deak, M, Gray, A, Walker, KS	Biochem J	1999