AKT binds PDPK1

Stable Identifier
R-HSA-2317314
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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AKT binds PDPK1
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Once phosphorylated on serine residue S473, AKT bound to PIP3 forms a complex with PIP3-bound PDPK1 i.e. PDK1 (Scheid et al. 2002, Sarabassov et al. 2005)

Literature References
PubMed ID Title Journal Year
15718470 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Ali, SM, Sabatini, DM, Sarbassov, DD, Guertin, DA

Science 2005
12167717 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

Woodgett, JR, Scheid, MP, Marignani, PA

Mol Cell Biol 2002
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
activation of protein kinase B activity (0032148)
Orthologous Events
AKT binds PDPK1 (Caenorhabditis elegans)
AKT binds PDPK1 (Canis familiaris)
AKT binds PDPK1 (Danio rerio)
AKT binds PDPK1 (Dictyostelium discoideum)
AKT binds PDPK1 (Drosophila melanogaster)
AKT binds PDPK1 (Gallus gallus)
AKT binds PDPK1 (Mus musculus)
AKT binds PDPK1 (Rattus norvegicus)
AKT binds PDPK1 (Saccharomyces cerevisiae)
AKT binds PDPK1 (Schizosaccharomyces pombe)
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Orlic-Milacic, M  (2012-06-09)
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