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KS(2),C4S-ACAN [extracellular region]
Stable Identifier
R-HSA-2318645
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
ACAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Aggrecan degradation by ADAMTSs (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
ECM proteoglycans (Homo sapiens)
Aggrecan binds Hyaluronan and HAPLN1 (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
Aggrecan:HA:HAPLN1 [extracellular region] (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
COMP binds collagen, fibronectin, aggrecan and matrilins (Homo sapiens)
COMP interactors [extracellular region] (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
COMP pentamer:COMP interactors [extracellular region] (Homo sapiens)
COMP interactors [extracellular region] (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N) bind lecticans (Homo sapiens)
Lecticans [extracellular region] (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N):Lecticans [extracellular region] (Homo sapiens)
Lecticans [extracellular region] (Homo sapiens)
Aggrecan [extracellular region] (Homo sapiens)
KS(2),C4S-ACAN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16112 ACAN
Gene Names
ACAN, AGC1, CSPG1, MSK16
Chain
signal peptide:1-16, chain:17-2530, chain:393-2530
Reference Genes
BioGPS Gene:176 ACAN
COSMIC (genes):ACAN ACAN
CTD Gene:176 ACAN
dbSNP Gene:176 ACAN
ENSEMBL:ENSG00000157766 ACAN
ENSEMBL_homo_sapiens_GENE:ENSG00000157766.19 ACAN
HGNC:319 ACAN
KEGG Gene (Homo sapiens):176 ACAN
Monarch:176 ACAN
NCBI Gene:176 ACAN
OMIM:155760 ACAN
UCSC:P16112 ACAN
Reference Transcript
RefSeq:NM_013227.3 ACAN
RefSeq:XM_011521314.1 ACAN
RefSeq:NM_001135.3 ACAN
Other Identifiers
11725358_a_at
11725359_a_at
16804506
176
205679_PM_x_at
205679_x_at
207692_PM_s_at
207692_s_at
217161_PM_x_at
217161_x_at
3607333
3607334
3607335
3607336
3607337
3607338
3607351
3607352
3607354
3607355
3607356
3607357
3607358
3607359
3607362
3607366
3607368
3607369
3607370
3607371
3607372
3607373
3607374
3607375
3607376
3607377
3607378
3607379
3607380
3607381
3607384
3607385
3607386
3607389
3607393
3607394
3607395
3607396
38965_at
39206_s_at
39207_r_at
7985786
A_14_P133773
A_23_P307310
A_33_P3218741
A_33_P3500167
GE536916
GO:0001501
GO:0002052
GO:0005198
GO:0005201
GO:0005515
GO:0005540
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0006508
GO:0007155
GO:0007417
GO:0010001
GO:0030021
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045202
GO:0046872
GO:0048856
GO:0062023
GO:0072534
HMNXSV003038872
ILMN_1693148
ILMN_1740675
ILMN_1777182
M55172_at
PH_hs_0000285
TC15000842.hg
TC15002348.hg
g4501990_3p_a_at
g6995993_3p_x_at
Participates
as a member of
Aggrecan [extracellular region] (Homo sapiens)
Other forms of this molecule
KS(2),C6S-ACAN(393-2415) [extracellular region]
KS(2),CSE-ACAN(393-2415) [extracellular region]
KS(2),C4S-ACAN(393-2415) [extracellular region]
KS(2),CSE-ACAN(17-392) [extracellular region]
KS(2),C4S-ACAN(17-392) [extracellular region]
KS(2),C6S-ACAN(17-392) [extracellular region]
KS(2),C4S-ACAN(376-2415) [extracellular region]
KS(2),CSE-ACAN(376-2415) [extracellular region]
KS(2),C6S-ACAN(376-2415) [extracellular region]
KS(2),C4S-ACAN(17-375) [extracellular region]
KS(2),CSE-ACAN(17-375) [extracellular region]
KS(2),C6S-ACAN(17-375) [extracellular region]
KS(2),CSE-ACAN(17-360) [extracellular region]
KS(2),C4S-ACAN(17-360) [extracellular region]
KS(2),C6S-ACAN(17-360) [extracellular region]
KS(2),CSE-ACAN(361-2415) [extracellular region]
KS(2),C6S-ACAN(361-2415) [extracellular region]
KS(2),C4S-ACAN(361-2415) [extracellular region]
KS(2),C6S-ACAN [extracellular region]
KS(2),CSE-ACAN [extracellular region]
ACAN [lysosomal lumen]
KS(2)-ACAN [lysosomal lumen]
KS(2)-ACAN [extracellular region]
KS(2)-ACAN [Golgi lumen]
KS(1)-ACAN [Golgi lumen]
N-glycan ACAN [Golgi lumen]
Gal-glycan ACAN [Golgi lumen]
Keratan(1)-ACAN [Golgi lumen]
Keratan(2)-ACAN [Golgi lumen]
Keratan(3)-ACAN [Golgi lumen]
Keratan(4)-ACAN [Golgi lumen]
Inferred To
ACAN [extracellular region]
(Bos taurus)
ACAN [extracellular region]
(Canis familiaris)
ACAN [extracellular region]
(Sus scrofa)
KS(2),C4S-ACAN [extracellular region]
(Gallus gallus)
KS(2),C4S-ACAN [extracellular region]
(Mus musculus)
KS(2),C4S-ACAN [extracellular region]
(Rattus norvegicus)
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (ChEBI:63520) at unknown position
Modification
alpha-NeuNAc-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal6S-(1->4)-beta-D-GlcNAc6S-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
XP_011519616.1
,
NP_037359.3
,
NP_001126.3
OpenTargets
ENSG00000157766
HPA
ENSG00000157766-ACAN
GeneCards
P16112
Ensembl
ENSG00000157766
,
ENST00000352105
,
ENST00000559004
,
ENST00000439576
,
ENSP00000453499
,
ENSP00000341615
,
ENSP00000387356
PRO
P16112
Pharos - Targets
P16112
Orphanet
15068
HMDB Protein
HMDBP01921
PDB
4MD4
,
7RDV
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
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