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ALOX5AP [nuclear envelope]
Stable Identifier
R-HSA-2318768
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Arachidonate 5-lipoxygenase-activating protein, FLAP
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Synthesis of Lipoxins (LX) (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
ALOX5 binds ALOX5 inhibitors (Homo sapiens)
ALOX5:ALOX5 inhibitors [nuclear envelope] (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
EXA4 is converted to EXC4 by LTC4S (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
LTA4 is converted to LTC4 by LTC4S (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
ALOX5AP [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20292 ALOX5AP
Gene Names
ALOX5AP, FLAP
Chain
chain:1-161
Reference Genes
BioGPS Gene:241 ALOX5AP
COSMIC (genes):ALOX5AP ALOX5AP
CTD Gene:241 ALOX5AP
dbSNP Gene:241 ALOX5AP
ENSEMBL:ENSG00000132965.10 ALOX5AP
HGNC:436 ALOX5AP
KEGG Gene (Homo sapiens):241 ALOX5AP
Monarch:241 ALOX5AP
NCBI Gene:241 ALOX5AP
OMIM:603700 ALOX5AP
UCSC:P20292 ALOX5AP
Reference Transcript
RefSeq:NM_001629.3 ALOX5AP
RefSeq:NM_001204406.1 ALOX5AP
Other Identifiers
11719479_at
16773662
204174_PM_at
204174_at
241
3484066
3484067
3484068
3484072
3484073
3484079
3484084
3484090
3484091
3484092
37099_at
60061_at
7968344
A_14_P112548
A_14_P202533
A_23_P2793
A_24_P347378
GE59771
GO:0002540
GO:0002675
GO:0003824
GO:0004051
GO:0004364
GO:0004464
GO:0004602
GO:0005515
GO:0005634
GO:0005635
GO:0005783
GO:0005789
GO:0005829
GO:0006629
GO:0006691
GO:0006954
GO:0008047
GO:0008289
GO:0016020
GO:0016021
GO:0016209
GO:0016491
GO:0016740
GO:0016829
GO:0019370
GO:0019372
GO:0019899
GO:0031965
GO:0042802
GO:0043226
GO:0044877
GO:0047485
GO:0050544
GO:0065003
GO:0070207
GO:0071277
GO:0098754
GO:0098772
GO:0098869
HMNXSV003019447
ILMN_1797875
M63262_at
PH_hs_0005601
TC13000100.hg
g4502058_3p_at
Participates
as a component of
ALOX5AP trimer [nuclear envelope] (Homo sapiens)
Inferred To
wu:fj65d02 [nuclear envelope]
(Danio rerio)
alox5ap [nuclear envelope]
(Xenopus tropicalis)
mgst [nuclear envelope]
(Dictyostelium discoideum)
Alox5ap [nuclear envelope]
(Mus musculus)
Alox5ap [nuclear envelope]
(Rattus norvegicus)
ALOX5AP [nuclear envelope]
(Bos taurus)
ALOX5AP [nuclear envelope]
(Canis familiaris)
ALOX5AP [nuclear envelope]
(Gallus gallus)
ALOX5AP [nuclear envelope]
(Sus scrofa)
Cross References
RefSeq
NP_001620.2
,
NP_001191335.1
ZINC - World Drugs
AL5AP_HUMAN
OpenTargets
ENSG00000132965
ZINC - FDA approved
AL5AP_HUMAN
ZINC - Substances
AL5AP_HUMAN
ZINC target
P20292
PRO
P20292
PDB
2Q7R
,
6VGC
,
2Q7M
,
6VGI
ZINC - Investigational
AL5AP_HUMAN
HPA
ENSG00000132965-ALOX5AP
GeneCards
P20292
Ensembl
ENSP00000369858
,
ENST00000380490
,
ENSG00000132965
Pharos - Targets
P20292
ZINC - Predictions - Purchasable
AL5AP_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15552 FFAR2
1
FFAR2 [plasma membrane]
(R-HSA-443944)
0.556
3
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