Reactome | DDR1 [plasma membrane]

DDR1 [plasma membrane]

Stable Identifier

R-HSA-2327723

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Epithelial discoidin domain-containing receptor 1, DDR1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q08345 DDR1

Gene Names

DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE

Chain

signal peptide:1-18, chain:19-913

Reference Genes

BioGPS Gene:780 DDR1

COSMIC - genes:DDR1 DDR1

CTD Gene:780 DDR1

dbSNP Gene:780 DDR1

ENSEMBL:ENSG00000204580 DDR1

HGNC:2730 DDR1

KEGG:hsa:780 DDR1

Monarch:780 DDR1

NCBI Gene:780 DDR1

OMIM:600408 DDR1

UCSC:Q08345 DDR1

Reference Transcript

Participates

as a component of

DDR1 dimer [plasma membrane] (Homo sapiens)

Inferred To

Ddr [plasma membrane] (Drosophila melanogaster)

DDR1 [plasma membrane] (Bos taurus)

DDR1 [plasma membrane] (Caenorhabditis elegans)

DDR1 [plasma membrane] (Canis familiaris)

DDR1 [plasma membrane] (Gallus gallus)

DDR1 [plasma membrane] (Mus musculus)

DDR1 [plasma membrane] (Rattus norvegicus)

DDR1 [plasma membrane] (Sus scrofa)

ddr1 [plasma membrane] (Danio rerio)

ddr1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_016866757.1, NP_001374839.1, NP_001374837.1, NP_001284582.1, XP_011513189.1, XP_054187116.1, XP_054186618.1, XP_047275288.1, NP_001374846.1, XP_054212345.1, XP_054212349.1, NP_001374822.1, NP_001374841.1, XP_054187123.1, XP_054185855.1, NP_001374831.1, NP_001374829.1, NP_001189452.2, XP_054212348.1, XP_054186619.1, XP_054212344.1, XP_054187115.1, NP_001397798.1, XP_054185853.1, XP_054186617.1, NP_001374840.1, NP_001374842.1, NP_001189450.1, XP_054186625.1, XP_054185852.1, XP_054185856.1, XP_054185850.1, XP_011513186.1, XP_054187120.1, NP_054699.2, XP_047275286.1, XP_054212347.1, XP_054186626.1, XP_054186622.1, NP_001374828.1, NP_001374847.1, NP_001374845.1, NP_054700.2, XP_054212350.1, XP_024302308.1, NP_001374827.1, NP_001374825.1, XP_054187122.1, NP_001945.3, NP_001374843.1, NP_001374823.1, XP_054187118.1, XP_054187119.1, XP_054185851.1, XP_047275289.1, XP_054186616.1, XP_047275283.1, NP_001374833.1, NP_001284583.1, XP_054187117.1, XP_047275285.1, XP_054186623.1, XP_054212346.1, XP_054187114.1, NP_001374821.1, NP_001374844.1, NP_001284581.1, XP_054186621.1, NP_001374832.1, NP_001374838.1, XP_054212351.1, XP_024302309.1, XP_054187113.1, XP_054185854.1, NP_001374830.1, XP_047275284.1, NP_001374824.1, XP_054212343.1, NP_001189451.1, NP_001374826.1, XP_054186620.1

ZINC - World Drugs

DDR1_HUMAN

Guide to Pharmacology - Targets

1843

OpenTargets

ENSG00000204580

ENSEMBL

ENSP00000416145, ENSP00000415730, ENSP00000365752, ENSG00000234078, ENSP00000397769, ENSP00000449238, ENST00000548133, ENST00000449518, ENSP00000318217, ENSP00000400393, ENSP00000449611, ENSP00000422442, ENSP00000479204, ENST00000376570, ENSP00000259875, ENSP00000449255, ENSP00000383265, ENSP00000448377, ENSP00000449307, ENST00000418800, ENST00000548962, ENST00000400491, ENST00000427053, ENST00000376569, ENST00000454774, ENSP00000383336, ENSG00000215522, ENST00000412329, ENST00000552068, ENST00000550384, ENST00000415092, ENST00000552721, ENST00000553015, ENST00000400486, ENSP00000383338, ENSP00000391805, ENST00000452441, ENST00000400411, ENST00000453510, ENSP00000365753, ENSP00000405039, ENSG00000137332, ENSP00000484013, ENSP00000383262, ENST00000508312, ENST00000430933, ENST00000550395, ENSP00000447474, ENSP00000383261, ENSP00000414285, ENST00000421229, ENSP00000427552, ENSP00000448115, ENST00000617572, ENST00000549026, ENSP00000401208, ENSP00000479195, ENSP00000401397, ENSP00000365751, ENSP00000365754, ENSP00000407699, ENST00000376575, ENSG00000204580, ENSP00000405540, ENST00000400414, ENST00000400492, ENSP00000365759, ENSP00000406091, ENST00000513240, ENST00000618059, ENST00000620318, ENST00000621544, ENSP00000383337, ENSP00000383334, ENST00000482873, ENST00000376568, ENST00000376567, ENSP00000421978, ENST00000383377, ENSG00000230456, ENST00000324771, ENSP00000416183, ENST00000454612, ENST00000429699, ENST00000400489, ENSP00000372868, ENST00000400488, ENSP00000449190, ENST00000419412, ENSP00000383339, ENST00000400410, ENST00000259875, ENSP00000484588

ZINC - FDA approved

DDR1_HUMAN

ZINC - Substances

DDR1_HUMAN

ZINC - Biogenic

DDR1_HUMAN

ZINC target

Q08345

PRO

Q08345

GlyGen

Q08345

PDB

7BE6, 6GWR, 4BKJ, 5FDP, 5BVO, 6FEX, 6FEW, 5SAX, 6HP9, 5BVN, 5SB1, 6FIN, 5SAW, 5SB0, 6Y23, 5SAZ, 5SAY, 5BVW, 6BRJ, 5FDX, 5SB2, 4CKR, 6FIO, 8PE9, 5SAV, 3ZOS, 6FIL, 6FIQ, 5BVK, 5SAU, 6BSD, 7FEH, 7BCM, 4AG4

ZINC - Investigational

DDR1_HUMAN

IntEnz

2.7.10.1

GeneCards

DDR1

HPA

ENSG00000204580-DDR1

Pharos - Targets

Q08345

ZINC - Predictions - Purchasable

DDR1_HUMAN

HMDB Protein

HMDBP01146

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.581	3
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.576	4
UniProt:P80370 DLK1	1	DLK1 [plasma membrane] (R-HSA-1604447)	0.527	2

Cite Us!