Fibrillin-1 binds integrins

Stable Identifier
R-HSA-2328037
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Fibrillin-1 splice variants that include the RGD sequence located in the fourth 8-cysteine domain mediate cell adhesion, binding integrin alphaVbeta3 (Pfaff et al. 1996), alpha5beta1 (Bax et al. 2003) and alphaVbeta6 (Jovanovic et al. 2008). AlphaVbeta3 has the highest affinity for fibrillin-1. Integrin alphaVbeta3 is a high-affinity fibrillin-1 receptor (K(d) approximately 40 nM), whereas integrins alphaVbeta6 and alpha5beta1 show moderate-affinity (K(d) approximately 450 nM) and low-affinity (K(d) >1 microM) binding respectively (Jovanovic et al. 2008).
Literature References
PubMed ID Title Journal Year
8617364 Cell adhesion and integrin binding to recombinant human fibrillin-1

Pfaff, M, Timpl, R, Sakai, LY, Reinhardt, DP

FEBS Lett. 1996
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!