Formation of lysino-5-ketonorleucine cross-links

Stable Identifier
R-HSA-2395314
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Formation of lysino-5-ketonorleucine cross-links
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In bone, cross-links are formed between telopeptide hydroxallysine residues and helical lysines (Robins & Bailey 1975). The resulting Schiff base undergoes Amadori rearrangement to form lysino-5-ketonorleucine (LKNL).
Literature References
PubMed ID Title Journal Year
1237296 The chemistry of the collagen cross-links. The mechanism of stabilization of the reducible intermediate cross-links

Robins, SP, Bailey, AJ

Biochem. J. 1975
  Dynamics of Bone and Cartilage Metabolism

Seibel, MJ, Robins, SP, Bilezikian, JP

  2006
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Orthologous Events
Formation of lysino-5-ketonorleucine cross-links (Bos taurus)
Formation of lysino-5-ketonorleucine cross-links (Caenorhabditis elegans)
Formation of lysino-5-ketonorleucine cross-links (Canis familiaris)
Formation of lysino-5-ketonorleucine cross-links (Danio rerio)
Formation of lysino-5-ketonorleucine cross-links (Gallus gallus)
Formation of lysino-5-ketonorleucine cross-links (Mus musculus)
Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)
Formation of lysino-5-ketonorleucine cross-links (Sus scrofa)
Formation of lysino-5-ketonorleucine cross-links (Xenopus tropicalis)
Authored
Jupe, S  (2012-04-30)
Reviewed
Raleigh, S  (2012-10-08)
Ricard-Blum, S  (2012-11-19)
Kalamajski, S  (2012-10-08)
Created
Jupe, S  (2012-06-29)
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