Reactome | Recruitment of GADS:SLP-76 to p-5Y-LAT

Recruitment of GADS:SLP-76 to p-5Y-LAT

Stable Identifier

R-HSA-2396561

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Gads/GRAP2 (GRB2-related adapter protein 2) is member of the GRB2 adaptor family with a central SH2 domain and linker region flanked by amino- and carboxy-terminal SH3 domains. SLP-76 associates constitutively via its central 20-amino acid proline-rich domain with the C-terminal SH3 domain of Gads, which recruits it to LAT following receptor stimulation. Upon LAT phosphorylation, Gads:SLP-76 complex principally binds to phosphorylated LAT tyrosine 191, with a reduced amount of binding to phosphorylated tyrosine 171 and no interaction with phosphorylated tyrosines 132 or 226 (Houtman et al. 2004, Zhu et al. 2003). Gads may promote cross-talk between the LAT and SLP-76 signaling complexes, thereby coupling membrane-proximal events to downstream signaling pathways (Liu et al. 1999). The LAT-Gads-SLP-76 complex creates a platform for the recruitment of multiple signaling molecules, including PLCgamma1, GRB2, NCK, Rho GEFs, VAV and the Tec-family kinases ITK and BTK (Liu et al. 1999 & 2001, Asada et al. 1999, Yablonski et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11390650	Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT Kadlecek, T, Yablonski, D, Weiss, A	Mol Cell Biol	2001
10224278	Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT Ishii, N, Takeshita, T, Tanaka, N, Sasaki, Y, Konno, T, Asada, H, Sugamura, K, Endo, K, Tsuchiya, S, Kasai, H	J. Exp. Med.	1999
10021361	The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors Liu, SK, McGlade, CJ, Koretzky, GA, Fang, N	Curr. Biol.	1999