PIK3R1 R574I [plasma membrane]

Stable Identifier
R-HSA-2399536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PIK3R1 Arg574Ile
Icon
PIK3R1 R574I [plasma membrane] icon
PIK3R1 R574I [plasma membrane] icon
Locations in the PathwayBrowser
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General
Similar to other PIK3R1 iSH2 domain mutations found in cancer, substitution of arginine residue with isoleucine at position 574 of PIK3R1 is expected to relieve inhibitory effect on the catalytic subunit of PI3K, PIK3CA, resulting in constitutive activity of PI3K complex that contains PIK3R1 R574I mutant (Jaiswal et al. 2009).
Literature References
PubMed ID Title Journal Year
19962665 Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

Yue, P, Kaminker, JS, Kan, Z, Modrusan, Z, Dbouk, HA, Kenski, DM, Stinson, J, Waring, P, Janakiraman, V, Stern, HM, Wang, W, Jaiswal, BS, Lorenzo, M, Peters, BA, Seshagiri, S, Chaudhuri, S, Eby, M, Bowman, KK, Wu, J, Kljavin, NM, Dela Vega, T, Backer, JM, de Sauvage, FJ, Li, H

Cancer Cell 2009
External Reference Information
External Reference
UniProt:P27986 PIK3R1
Gene Names
PIK3R1, GRB1
Chain
initiator methionine:, chain:2-724
Reference Genes
COSMIC (genes):PIK3R1 PIK3R1
dbSNP Gene:5295 PIK3R1
ENSEMBL:ENSG00000145675 PIK3R1
Participates
as a candidate of
Other forms of this molecule
PIK3R1 [plasma membrane]
PIK3R1 [cytosol]
K63polyUb-PIK3R1 [cytosol]
PIK3R1 R574T [plasma membrane]
PIK3R1 D560H [plasma membrane]
PIK3R1 N564K [plasma membrane]
PIK3R1 K459del [plasma membrane]
PIK3R1 N564D [plasma membrane]
PIK3R1 D560Y [plasma membrane]
PIK3R1 R574_T576del [plasma membrane]
PIK3R1 H450_E451del [plasma membrane]
PIK3R1 Y463_L466del [plasma membrane]
PIK3R1 K379E [plasma membrane]
PIK3R1 G376R [plasma membrane]
p-Y-PIK3R1 [cytosol]
Modified Residues
Name
L-arginine 574 replaced with L-isoleucine
Coordinate
574
PsiMod
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
L-isoleucine residue [MOD:00019]
A protein modification that effectively converts a source amino acid residue to an L-isoleucine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
COSMIC
Interactors (78)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P42336 PIK3CA  20 0.967 64
 UniProt:P09619 PDGFRB  3 0.951 21
 UniProt:P22681 CBL  20 0.94 16
 UniProt:P21860 ERBB3      0.921 41
 UniProt:P35568 IRS1  5 0.921 13
 UniProt:P10747 CD28  3 0.903 10
 UniProt:O00329 PIK3CD  2 0.888 9
 UniProt:P62993 GRB2  1 0.863 6
 UniProt:P42338 PIK3CB  1 0.84 6
 UniProt:P29353 SHC1  5 0.816 6
 UniProt:P00533 EGFR  20 0.81 7
 UniProt:P08069 IGF1R  3 0.803 6
 UniProt:Q13480 GAB1  4 0.796 33
 UniProt:P60953 CDC42  3 0.794 10
 UniProt:P12931 SRC  6 0.779 7
 UniProt:P06213 INSR  6 0.767 5
 UniProt:P04626 ERBB2  20 0.759 12
 UniProt:P10721 KIT  20 0.749 19
 UniProt:P62999  6 0.717 5
 UniProt:P62994 Grb2  3 0.688 3
 UniProt:Q9Y4H2 IRS2  4 0.688 3
 UniProt:P03496 NS  2 0.659 6
 UniProt:P11362 FGFR1  9 0.644 6
 UniProt:O14654 IRS4  2 0.643 3
 UniProt:P16410 CTLA4  2 0.643 3
 UniProt:P30874 SSTR2  1 0.639 5
 UniProt:P04629 NTRK1  4 0.624 4
 UniProt:O00459 PIK3R2  3 0.623 4
 UniProt:Q9Y6W8 ICOS  1 0.623 5
 UniProt:P45983 MAPK8  3 0.623 6
 UniProt:P10398 ARAF  4 0.611 3
 UniProt:Q8TDQ0 HAVCR2  1 0.597 3
 UniProt:P30530 AXL  2 0.597 3
 UniProt:Q99152 VP3      0.591 3
 UniProt:P61981 YWHAG  1 0.589 2
 UniProt:P43405 SYK  6 0.581 5
 UniProt:P41970 ELK3      0.573 2
 UniProt:P48023 FASLG  1 0.571 2
 UniProt:P29376 LTK  2 0.569 3
 UniProt:P35570 Irs1  7 0.564 2
 UniProt:Q9UQC2 GAB2  5 0.564 2
 UniProt:Q13111 CAF1A      0.564 2
 UniProt:P19793 RXRA  4 0.556 8
 UniProt:P42858 HTT  1 0.553 7
 UniProt:Q13746 Q13746      0.544 3
 UniProt:P16885 PLCG2  8 0.536 2
 UniProt:O43493 TGOLN2  8 0.536 2
 UniProt:P46109 CRKL  2 0.536 2
 UniProt:Q07889 SOS1  3 0.536 3
 UniProt:Q92569 PIK3R3  2 0.527 2
 UniProt:P63104 YWHAZ  2 0.527 2
 UniProt:P09564 CD7      0.527 2
 UniProt:Q86VI4-3 LAPTM4B      0.524 2
 UniProt:Q8BM65-4 NYAP2      0.524 3
 UniProt:Q8IY22 CMIP      0.524 2
 UniProt:P48025 Syk  8 0.524 2
 UniProt:Q6PFX7 NYAP1      0.524 4
 UniProt:O15455 TLR3  6 0.524 2
 UniProt:P21709 EPHA1  2 0.519 2
 UniProt:P17948 FLT1  1 0.519 3
 UniProt:Q9Y2I1 NISCH  1 0.508 2
 UniProt:P43626 KIR2DL1  1 0.488 2
 UniProt:P03372 ESR1  10 0.483 7
 UniProt:P46108 CRK  1 0.483 2
 UniProt:Q01973 ROR1  2 0.483 2
 UniProt:P58753 TIRAP  2 0.463 3
 UniProt:P21145 MAL      0.463 3
 UniProt:O00329-2 PIK3CD      0.463 2
 UniProt:P30875  1 0.462 2
 UniProt:O14733 MAP2K7  4 0.462 3
 UniProt:Q16584 MAP3K11  1 0.462 3
 UniProt:P29350 PTPN6  5 0.462 2
 UniProt:P06127 CD5      0.462 2
 UniProt:P45984 MAPK9  3 0.462 3
 UniProt:P63000 RAC1  6 0.462 5
 UniProt:P25963 NFKBIA  9 0.462 2
 UniProt:P32927 CSF2RB  6 0.462 4
 UniProt:O43561 LAT  3 0.462 4
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