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PIK3R1 K459del [plasma membrane]
Stable Identifier
R-HSA-2399554
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PIK3R1 Lys459del
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K mutants [plasma membrane] (Homo sapiens)
PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
PIK3R1 mutants [plasma membrane] (Homo sapiens)
PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
PIK3R1 K459del [plasma membrane] (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K mutants [plasma membrane] (Homo sapiens)
PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
PIK3R1 mutants [plasma membrane] (Homo sapiens)
PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
PIK3R1 K459del [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K mutants [plasma membrane] (Homo sapiens)
PIK3R1 mutants:PIK3CA [plasma membrane] (Homo sapiens)
PIK3R1 mutants [plasma membrane] (Homo sapiens)
PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
PIK3R1 K459del [plasma membrane] (Homo sapiens)
General
The inframe deletion of lysine residue at position 549 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 K549del mutant (Urick et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21478295
PIK3R1 (p85?) is somatically mutated at high frequency in primary endometrial cancer
Urick, ME
,
Rudd, ML
,
Godwin, AK
,
Sgroi, D
,
Bell, DW
,
Merino, M
Cancer Res.
2011
External Reference Information
External Reference
UniProt:P27986 PIK3R1
Gene Names
PIK3R1, GRB1
Chain
initiator methionine:, chain:2-724
Reference Genes
BioGPS Gene:5295 PIK3R1
COSMIC (genes):PIK3R1 PIK3R1
CTD Gene:5295 PIK3R1
dbSNP Gene:5295 PIK3R1
ENSEMBL:ENSG00000145675 PIK3R1
ENSEMBL_homo_sapiens_GENE:ENSG00000145675.16 PIK3R1
HGNC:8979 PIK3R1
KEGG Gene (Homo sapiens):5295 PIK3R1
Monarch:5295 PIK3R1
NCBI Gene:5295 PIK3R1
OMIM:171833 PIK3R1
UCSC:P27986 PIK3R1
Reference Transcript
RefSeq:NM_181523.2 PIK3R1
RefSeq:NM_181504.3 PIK3R1
RefSeq:XM_005248542.3 PIK3R1
RefSeq:NM_181524.1 PIK3R1
RefSeq:XM_017009585.1 PIK3R1
RefSeq:NM_001242466.1 PIK3R1
Other Identifiers
11733017_a_at
11733018_s_at
11733019_a_at
11739539_a_at
11739540_a_at
11739541_a_at
11748670_a_at
11754631_x_at
1269_at
16985518
212239_PM_at
212239_at
212240_PM_s_at
212240_s_at
212249_PM_at
212249_at
2813091
2813092
2813093
2813094
2813095
2813101
2813102
2813103
2813125
2813127
2813132
2813134
2813135
2813137
2813139
2813140
2813142
2813143
2813145
2813146
2813148
2813150
2813152
2813153
2813154
2813155
2813156
2813157
2813158
2813159
35373_at
44015_at
5295
55623_at
73148_at
73150_g_at
77475_at
8105778
A_14_P105607
A_23_P144980
A_24_P29401
GE58013
GE85962
GE88834
GO:0001678
GO:0001784
GO:0001953
GO:0002376
GO:0002687
GO:0003824
GO:0005068
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005801
GO:0005829
GO:0005886
GO:0005911
GO:0005942
GO:0005943
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006629
GO:0006886
GO:0006913
GO:0006955
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0008286
GO:0008625
GO:0008630
GO:0010592
GO:0012501
GO:0015031
GO:0016020
GO:0016740
GO:0019209
GO:0019221
GO:0019903
GO:0023052
GO:0030154
GO:0030183
GO:0030217
GO:0030316
GO:0032760
GO:0032869
GO:0033120
GO:0034143
GO:0034330
GO:0034446
GO:0034644
GO:0034976
GO:0035014
GO:0035655
GO:0036312
GO:0042307
GO:0043066
GO:0043125
GO:0043226
GO:0043491
GO:0043548
GO:0043559
GO:0043560
GO:0045671
GO:0045944
GO:0046326
GO:0046854
GO:0046935
GO:0046982
GO:0048009
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050821
GO:0051491
GO:0051492
GO:0051497
GO:0052742
GO:0055085
GO:0060090
GO:0060396
GO:0072659
GO:0097529
GO:0098542
GO:0098772
GO:0120183
GO:0140767
GO:0141038
GO:1900103
GO:1903076
GO:1903078
GO:1990578
HMNXSV003040338
Hs.6241.0.S1_3p_a_at
Hs.6241.0.S2_3p_at
Hs.6241.0.S3_3p_at
ILMN_1689057
ILMN_1691433
ILMN_1760303
ILMN_2289433
ILMN_2398235
M61906_at
PH_hs_0021977
RNA147745|p0849_imsncRNA655
TC05000291.hg
Participates
as a member of
PIK3R1 iSH2 domain mutants [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y-PIK3R1 [cytosol]
PIK3R1 G376R [plasma membrane]
PIK3R1 K379E [plasma membrane]
PIK3R1 Y463_L466del [plasma membrane]
PIK3R1 H450_E451del [plasma membrane]
PIK3R1 R574_T576del [plasma membrane]
PIK3R1 D560Y [plasma membrane]
PIK3R1 N564D [plasma membrane]
PIK3R1 N564K [plasma membrane]
PIK3R1 D560H [plasma membrane]
PIK3R1 R574I [plasma membrane]
PIK3R1 R574T [plasma membrane]
K63polyUb-PIK3R1 [cytosol]
PIK3R1 [cytosol]
PIK3R1 [plasma membrane]
Modified Residues
Name
Deletion of residues 459 to 459
Disease
Name
Identifier
Synonyms
endometrial cancer
DOID:1380
primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_001229395.1
,
NP_852664.1
,
NP_852556.2
,
XP_005248599.1
,
XP_016865074.1
,
NP_852665.1
ZINC - World Drugs
P85A_HUMAN
Guide to Pharmacology - Targets
2503
OpenTargets
ENSG00000145675
ZINC - Substances
P85A_HUMAN
ZINC target
P27986
ZINC - Biogenic
P85A_HUMAN
PRO
P27986
PDB
8TS7
,
7MYN
,
7RNS
,
5XGJ
,
7CIO
,
5GJI
,
5XGI
,
5XGH
,
5M6U
,
8DD8
,
2V1Y
,
1PBW
,
1PKT
,
5SX9
,
2IUG
,
2IUH
,
1A0N
,
3I5R
,
1H9O
,
4A55
,
6PYU
,
4OVV
,
4OVU
,
8GUB
,
7PG6
,
8DCP
,
1PKS
,
5SXC
,
5SXB
,
7PG5
,
8V8H
,
4L23
,
5UK8
,
5SXD
,
5UBT
,
8SBC
,
5SX8
,
8TSB
,
5SWT
,
7LM2
,
7LQ1
,
8TU6
,
8ILR
,
8TSA
,
5SW8
,
8ILS
,
4ZOP
,
4WAF
,
4YKN
,
5UKJ
,
6PYR
,
5ITD
,
3HIZ
,
5VLR
,
5SWG
,
1PHT
,
8TSD
,
4L2Y
,
4L1B
,
5SXK
,
5SXJ
,
8V8V
,
8DCX
,
6NCT
,
8DD4
,
5FI4
,
5SXF
,
5AUL
,
8V8U
,
5SXE
,
7MYO
,
5SXI
,
2RD0
,
4JPS
,
8V8I
,
8V8J
,
8TDU
,
5SWO
,
1PIC
,
8W9B
,
8SBJ
,
2IUI
,
8TSC
,
5SXA
,
8H37
,
8W9A
,
1AZG
,
8ILV
,
7TZ7
,
8H36
,
8AM0
,
5UL1
,
3HHM
,
8TGD
,
5SWP
,
8TS8
,
3I5S
,
8TS9
,
5SWR
ZINC - Metabolites
P85A_HUMAN
COSMIC
COSV57126622
HPA
ENSG00000145675-PIK3R1
GeneCards
P27986
Ensembl
ENST00000697467
,
ENST00000697458
,
ENSG00000145675
,
ENSP00000513333
,
ENST00000517643
,
ENSP00000513325
,
ENSP00000430098
,
ENSP00000323512
,
ENST00000523872
,
ENSP00000513316
,
ENSP00000338554
,
ENST00000336483
,
ENSP00000513319
,
ENSP00000428056
,
ENST00000521381
,
ENSP00000429277
,
ENST00000320694
,
ENST00000697461
,
ENST00000521657
Pharos - Targets
P27986
ZINC - Predictions - Purchasable
P85A_HUMAN
Orphanet
22044
HMDB Protein
HMDBP03978
Interactors (78)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.967
64
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.951
21
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.94
16
UniProt:P35568 IRS1
5
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
IRS1 [cytosol]
(R-HSA-74769)
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
0.921
13
UniProt:P21860 ERBB3
0.921
41
UniProt:P10747 CD28
3
CD28 [cytosol]
(R-HSA-167628)
p-Y191-CD28 [plasma membrane]
(R-HSA-388756)
CD28 [plasma membrane]
(R-HSA-167632)
0.903
10
UniProt:O00329 PIK3CD
2
PIK3CD [cytosol]
(R-HSA-1806204)
PIK3CD [plasma membrane]
(R-HSA-392274)
0.888
9
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.863
6
UniProt:P42338 PIK3CB
1
PIK3CB [cytosol]
(R-HSA-74788)
0.84
6
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.816
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.81
7
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.803
6
UniProt:Q13480 GAB1
4
GAB1 [cytosol]
(R-HSA-179795)
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.796
33
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.794
10
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.779
7
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.767
5
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.759
12
UniProt:P10721 KIT
20
KIT C443Y [plasma membrane]
(R-HSA-9680045)
KIT T417_D419delinsY [plasma membrane]
(R-HSA-9680110)
KIT S476I [plasma membrane]
(R-HSA-9680090)
KIT K509I [plasma membrane]
(R-HSA-9680177)
KIT D419A [plasma membrane]
(R-HSA-9680051)
KIT D419del [plasma membrane]
(R-HSA-9680079)
KIT S501_A502dup [plasma membrane]
(R-HSA-9680105)
KIT D419G [plasma membrane]
(R-HSA-9680057)
KIT N505_F508dup [plasma membrane]
(R-HSA-9680085)
KIT C443S [plasma membrane]
(R-HSA-9680038)
KIT D419N [plasma membrane]
(R-HSA-9680071)
KIT S476N [plasma membrane]
(R-HSA-9680097)
KIT D419H [plasma membrane]
(R-HSA-9680066)
KIT V560_L576del [plasma membrane]
(R-HSA-9670336)
KIT Y823N [plasma membrane]
(R-HSA-9669591)
KIT Y823C [plasma membrane]
(R-HSA-9669585)
p6Y-KIT Y823D [plasma membrane]
(R-HSA-9669628)
p7Y-KIT D816V [plasma membrane]
(R-HSA-9669612)
p7Y-KIT K642E [plasma membrane]
(R-HSA-9669596)
p7Y-KIT N822K [plasma membrane]
(R-HSA-9669617)
0.749
19
UniProt:P62999
6
RAC1 [ficolin-1-rich granule membrane]
(R-CFA-6804802-2)
RAC1 [secretory granule membrane]
(R-CFA-6804770-2)
GGC-PalmC-RAC1 [plasma membrane]
(R-CFA-2316446-2)
RAC1 [endoplasmic reticulum membrane]
(R-CFA-5672076-2)
RAC1 [cytosol]
(R-CFA-442615-2)
RAC1 [plasma membrane]
(R-CFA-351141-2)
0.717
5
UniProt:Q9Y4H2 IRS2
4
IRS2 [plasma membrane]
(R-HSA-2428927)
IRS2 [cytosol]
(R-HSA-57528)
p-Y-IRS2 [cytosol]
(R-HSA-74774)
p-Y-IRS2 [plasma membrane]
(R-HSA-198334)
0.688
3
UniProt:P62994 Grb2
3
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-74686)
0.688
3
UniProt:P03496 NS
2
NS1 [nucleoplasm]
(R-FLU-169113)
NS1 [cytosol]
(R-FLU-169118)
0.659
6
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.644
6
UniProt:O14654 IRS4
2
p-Y-IRS4 [plasma membrane]
(R-HSA-2424302)
IRS4 [plasma membrane]
(R-HSA-2424297)
0.643
3
UniProt:P16410 CTLA4
2
p-Y201,Y218-CTLA4 [plasma membrane]
(R-HSA-388754)
CTLA4 [plasma membrane]
(R-HSA-179764)
0.643
3
UniProt:P30874 SSTR2
1
SSTR2 [plasma membrane]
(R-HSA-374757)
0.639
5
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.624
4
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.623
4
UniProt:Q9Y6W8 ICOS
1
ICOS [plasma membrane]
(R-HSA-9845023)
0.623
5
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.623
6
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.611
3
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.597
3
UniProt:P30530 AXL
2
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.597
3
UniProt:Q99152 VP3
0.591
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.589
2
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.581
5
UniProt:P41970 ELK3
0.573
2
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.571
2
UniProt:P29376 LTK
2
p-6Y-LTK [plasma membrane]
(R-HSA-9842578)
LTK [plasma membrane]
(R-HSA-9842564)
0.569
3
UniProt:Q13111 CAF1A
0.564
2
UniProt:P35570 Irs1
7
Irs1 [cytosol]
(R-RNO-1168867)
phospho-Irs1 [plasma membrane]
(R-RNO-2445090)
Irs1 [plasma membrane]
(R-RNO-2425392)
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-74769)
phospho-Irs1 [cytosol]
(R-RNO-74772)
phospho-Irs1 [plasma membrane]
(R-RNO-198366)
0.564
2
UniProt:Q9UQC2 GAB2
5
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
GAB2 [cytosol]
(R-HSA-508239)
0.564
2
UniProt:P19793 RXRA
4
RXRA [cytosol]
(R-HSA-9619757)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.556
8
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.553
7
UniProt:Q13746 Q13746
0.544
3
UniProt:P16885 PLCG2
8
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [plasma membrane]
(R-HSA-114601)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [cytosol]
(R-HSA-984806)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y-PLCG2 [cytosol]
(R-HSA-9029105)
0.536
2
UniProt:O43493 TGOLN2
8
TGOLN2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869127)
TGOLN2 [plasma membrane]
(R-HSA-8864458)
TGOLN2 [Golgi membrane]
(R-HSA-434342)
TGOLN2 [cytoplasmic vesicle membrane]
(R-HSA-429818)
TGOLN2 [trans-Golgi network membrane]
(R-HSA-6811008)
TGOLN2 [transport vesicle]
(R-HSA-6811011)
p-TGOLN2 [endoplasmic reticulum lumen]
(R-HSA-8956886)
TGOLN2 [endoplasmic reticulum lumen]
(R-HSA-8956702)
0.536
2
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.536
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.536
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
2
UniProt:P09564 CD7
0.527
2
UniProt:Q86VI4-3 LAPTM4B
0.524
2
UniProt:Q8BM65-4 NYAP2
0.524
3
UniProt:Q8IY22 CMIP
0.524
2
UniProt:Q6PFX7 NYAP1
0.524
4
UniProt:O15455 TLR3
6
TLR3 E746* [endosome membrane]
(R-HSA-5602730)
TLR3 P554S [endosome membrane]
(R-HSA-5602428)
TLR3 [endoplasmic reticulum membrane]
(R-HSA-1679057)
TLR3 [endolysosome membrane]
(R-HSA-167941)
TLR3 [Golgi membrane]
(R-HSA-1678955)
TLR3 [endosome membrane]
(R-HSA-2000341)
0.524
2
UniProt:P48025 Syk
8
p-Syk [cytosol]
(R-MMU-9676057)
phospho-p-Y-SYK [cytosol]
(R-MMU-9705732)
phospho-p-Y-SYK [plasma membrane]
(R-MMU-429432)
Syk [cytosol]
(R-MMU-442293)
p-Y348,Y352,Y525,Y526-Syk [cytosol]
(R-MMU-5621123)
phospho-p-6Y-SYK [cytosol]
(R-MMU-1861712)
phospho-p-Y348-SYK [cytosol]
(R-MMU-437953)
SYK [cytosol]
(R-MMU-58268)
0.524
2
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.519
2
UniProt:P17948 FLT1
1
VEGFR1 [plasma membrane]
(R-HSA-3004464)
0.519
3
UniProt:Q9Y2I1 NISCH
1
NISCH [cytosol]
(R-HSA-9691384)
0.508
2
UniProt:P43626 KIR2DL1
1
KIR2DL1 [plasma membrane]
(R-HSA-199538)
0.488
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.483
7
UniProt:Q01973 ROR1
2
ROR1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140727)
ROR1 [plasma membrane]
(R-HSA-197814)
0.483
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.483
2
UniProt:P21145 MAL
0.463
3
UniProt:O00329-2 PIK3CD
0.463
2
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.463
3
UniProt:P30875
1
Sstr2 [plasma membrane]
(R-MMU-374757)
0.462
2
UniProt:P06127 CD5
0.462
2
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.462
3
UniProt:O14733 MAP2K7
4
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.462
3
UniProt:Q16584 MAP3K11
1
MAP3K11 [cytosol]
(R-HSA-449607)
0.462
3
UniProt:O43561 LAT
3
p-Y200,Y220-LAT [plasma membrane]
(R-HSA-434829)
p-5Y-LAT [plasma membrane]
(R-HSA-202364)
LAT [plasma membrane]
(R-HSA-202322)
0.462
4
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.462
5
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.462
2
UniProt:P32927 CSF2RB
6
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
0.462
4
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.462
2
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