AKT1 E17K gain-of-function mutant preserves the ability to phosphorylate CDKN1B i.e. p27Kip1 (Malanga et al. 2008) and is expected to phosphorylate CDKN1A i.e. p21Cip1, like the wild-type AKT (Viglietto et al. 2002), although this has not been experimentally tested.
Franco, R, De Rosa, N, Rocco, G, Savino, R, Malara, N, Malanga, D, Fabiani, F, Pirozzi, G, Scrima, M, De Marco, C, Tirino, V, De Gisi, S, Chiappetta, G, Viglietto, G
Tsichlis, P, Viglietto, G, Santoro, M, Bruni, P, Vinci, F, Motti, ML, Califano, D, Fusco, A, Chiappetta, G, Melillo, RM, D'Alessio, A, Bellacosa, A
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
Gain of function of p-T308,S473-AKT1 E17K [cytosol]
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