AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)

Stable Identifier
R-HSA-2399977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
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AKT1 E17K gain-of-function mutant is expected to phosphorylate AKT1S1 (PRAS40), like the wild-type AKT (Kovacina et al. 2003), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
12524439 Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

Kovacina, KS, Roth, RA, Schaefer, E, Birnbaum, MJ, Bae, SS, Park, GY, Guzzetta, AW

J Biol Chem 2003
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]

Physical Entity
p-T308,S473-AKT1 E17K [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
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