AKT1 E17K gain-of-function mutant is expected to phosphorylate TSC2 and inhibit it, like the wild-type AKT (Inoki et al. 2002, Manning et al. 2002), but this has not been experimentally tested.
protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
Gain of function of p-T308,S473-AKT1 E17K [cytosol]