AKT1 E17K mutant phosphorylates caspase-9

Stable Identifier
R-HSA-2399985
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT1 E17K gain-of-function mutant is expected to phosphorylate caspase-9 (CASP9), like the wild-type AKT (Cardone et al. 1998), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
9812896 Regulation of cell death protease caspase-9 by phosphorylation

Cardone, MH, Roy, N, Stennicke, HR, Salvesen, GS, Franke, TF, Stanbridge, E, Frisch, S, Reed, JC

Science 1998
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]

Normal reaction
Functional status

Gain of function of p-T308,S473-AKT1 E17K [cytosol]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
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