AKT1 E17K mutant phosphorylates CREB1

Stable Identifier
R-HSA-2399996
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AKT1 E17K mutant phosphorylates CREB1
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AKT1 E17K gain-of-function mutant is expected to phosphorylate CREB1, like the wild-type AKT (Du et al. 1998), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
9829964 CREB is a regulatory target for the protein kinase Akt/PKB

Du, K, Montminy, M

J Biol Chem 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]

Physical Entity
p-T308,S473-AKT1 E17K [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
AKT phosphorylates CREB1 (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
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