Reactome | RBP4:atROL binds TTR

RBP4:atROL binds TTR

Stable Identifier

R-HSA-2404134

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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In the bloodstream, circulating retinol binding protein 4 (RBP4, in complex with atROL), binds transthyretin (TTR, a 51 kDa protein) in a 1:1 molar complex (Naylor & Newcomer, 1999). The resultant TTR:RBP4:atROL complex is larger and therefore less susceptible to glomerular filtration, maintaining normal levels of retinoid and RBP4 in the circulation. In TTR-deficient mice, plasma levels of atROL and RBP4 were observed to be 5% of wild type levels, highlighting the importance of TTR binding to RBP4:atROL (Episkopou et al. 1993). TTR is also a transporter for thyroxine in the brain (not shown here) (Herbert et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
3714052	Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award Herbert, J, Zeviani, M, Goodman, DS, Makover, A, Fremeau, RT, Dwork, A, Pham, KT, Soprano, DR, Wilcox, JN, Zimmerman, EA	Neurology	1986
10052934	The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP Naylor, HM, Newcomer, ME	Biochemistry	1999
8384721	Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone Robertson, EJ, Maeda, S, Gaitanaris, GA, Episkopou, V, Shimada, K, Gottesman, ME, Nishiguchi, S	Proc. Natl. Acad. Sci. U.S.A.	1993