Reactome | IGF1R phosphorylates SHC1

IGF1R phosphorylates SHC1

Stable Identifier

R-HSA-2404193

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The phosphorylated IGF1R phosphorylates SHC1 (Giorgetti et al. 1994, Hernandez-Sanchez et al. 1995, Kim et al. 1998). Phosphorylation of SHC1 is sustained whereas phosphorylation of IRS2 by IGF1R is transient (Kim et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
8033892	Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor Pelicci, G, Pelicci, PG, Van Obberghen, E, Giorgetti, S	Eur. J. Biochem.	1994
9852124	Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling Feldman, EL, Cheng, HL, Margolis, B, Kim, B	J. Biol. Chem.	1998
7493944	The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis Kalebic, T, Blakesley, V, LeRoith, D, Hernández-Sánchez, C, Helman, L	J. Biol. Chem.	1995