Reactome | Sec-tRNA(Sec) binds to EEFSEC:GTP

Sec-tRNA(Sec) binds to EEFSEC:GTP

Stable Identifier

R-HSA-2408509

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The final product, selenocysteinyl transfer RNA (tRNA) for Sec (Sec-tRNASec) binds to selenocysteine-specific elongation factor (EEFSEC) aka SelB complexed with GTP. This complex is now ready to be delivered to the 80S ribosome. This reaction is inferred from the equivalent reaction in mouse.

Literature References

PubMed ID	Title	Journal	Year
11265756	Decoding apparatus for eukaryotic selenocysteine insertion Carlson, BA, Berry, MJ, Driscoll, DM, Tujebajeva, RM, Harney, JW, Hatfield, DL, Copeland, PR, Xu, XM	EMBO Rep.	2000
10970870	Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation Hubert, N, Yamada, K, Fagegaltier, D, Mizutani, T, Krol, A, Carbon, P	EMBO J.	2000