Reactome | tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer

tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer

Stable Identifier

R-HSA-2408526

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer

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The synthetic cycle of selenocysteine (Sec) synthesis starts with misacylation (serylation) of the cognate transfer RNA (tRNA) for Sec, tRNASec, with serine (Ser) by Serine--tRNA ligase (SARS) homodimer. The structural homology of tRNASec and tRNASer enables SARS to form Ser-tRNASec (Vincent et al. 1997, Amberg et al. 1996, Heckl et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9431993	Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase Hartlein, M, Vincent, C, Tarbouriech, N	Eur J Biochem	1997
9637248	Minimal tRNA(Ser) and tRNA(Sec) substrates for human seryl-tRNA synthetase: contribution of tRNA domains to serylation and tertiary structure Busch, K, Gross, HJ, Heckl, M	FEBS Lett.	1998
8890909	Selenocysteine synthesis in mammalia: an identity switch from tRNA(Ser) to tRNA(Sec) Amberg, R, Gross, HJ, Mizutani, T, Wu, XQ	J. Mol. Biol.	1996

Participants

Input

Output

Participates

as an event of

Selenocysteine synthesis (Homo sapiens)

Catalyst Activity

selenocysteine-tRNA ligase activity of SARS dimer [cytosol]

Physical Entity

SARS dimer [cytosol] (Homo sapiens)

Activity

selenocysteine-tRNA ligase activity (GO:0098619)

Authored

Williams, MG (2014-05-06)

Reviewed

Rush, MG (2015-08-30)

Created

Williams, MG (2012-07-17)

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