Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer

Stable Identifier
R-HSA-2408555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer
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O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS) tetramer catalyses the transformation of phosphoserine (Sep) into selenocysteine (Sec) by using selenophosphate (SELP) as a selenium donor to convert the phosphoserylated transfer RNA (tRNA) for Sec (Sep-tRNASec) into Sec-tRNASec (Palioura et al. 2009, Yuan et al. 2006).
Literature References
PubMed ID Title Journal Year
17142313 RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea

Palioura, S, Cardoso, AM, Salazar, JC, Yuan, J, Whitman, WB, Su, D, Söll, D, O'Donoghue, P, Hohn, MJ

Proc. Natl. Acad. Sci. U.S.A. 2006
19608919 The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation

Palioura, S, Sherrer, RL, Steitz, TA, Simonovic, M, Söll, D

Science 2009
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Catalyst Activity

O-phosphoseryl-tRNA(Sec) selenium transferase activity of PXLP-K284-SEPSECS tetramer [cytosol]

Physical Entity
PXLP-K284-SEPSECS tetramer [cytosol] (Homo sapiens)
Activity
O-phosphoseryl-tRNA(Sec) selenium transferase activity (GO:0098621)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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