PI3K phosphorylates PIP2 to PIP3

Stable Identifier
Reaction [transition]
Homo sapiens
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Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. Products of PI3K are involved in the regulation of PLC-gamma 1 and VAV activation. The PH domain of PLC-gamma 1 binds to PIP3 and is targeted to the membrane. PIP3 binds to the PH domain of VAV2/VAV3 and increases it activity and PI3K may also strongly stimulate VAV activity by converting an inhibitory regulator VAV to an activator (Toker & Cantley 1997, Fischer et al. 1998, Falasca et al. 1998).

Literature References
PubMed ID Title Journal Year
15536084 Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase

Moon, KD, Durden, DL, Post, CB, De, P, Geahlen, RL, Harrison, ML, Zhou, Q

J Biol Chem 2005
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane]

Orthologous Events
Cross References
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