Phosphoinositide 3-kinases (PI3Ks) are one of the downstream effectors of activated SYK. The p85 alpha regulatory subunit of PI3K has been shown to interact with SYK phospho-tyrosine Y323. In DAP12 signaling SYK acts via the PI3K-dependent pathway to control NK cell-mediated cytotoxicity. SYK-coupled PI3K is rapidly activated and triggers a sequential activation of VAV2/VA3, RAC1, PAK1, MEK and ERK to mediate NK cell-mediated lysis (Jiang et al. 2002, Moon et al. 2005).
Moon, KD, Durden, DL, Post, CB, De, P, Geahlen, RL, Harrison, ML, Zhou, Q
Zhong, B, Wei, S, Jiang, K, Corliss, BC, Gilvary, DL, Vivier, E, Hong-Geller, E, Djeu, JY
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