Reactome | p85 regulatory unit of PI3K binds p-6Y-SYK

p85 regulatory unit of PI3K binds p-6Y-SYK

Stable Identifier

R-HSA-2424482

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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p85 regulatory unit of PI3K binds p-6Y-SYK

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Phosphoinositide 3-kinases (PI3Ks) are one of the downstream effectors of activated SYK. The p85 alpha regulatory subunit of PI3K has been shown to interact with SYK phospho-tyrosine Y323. In DAP12 signaling SYK acts via the PI3K-dependent pathway to control NK cell-mediated cytotoxicity. SYK-coupled PI3K is rapidly activated and triggers a sequential activation of VAV2/VA3, RAC1, PAK1, MEK and ERK to mediate NK cell-mediated lysis (Jiang et al. 2002, Moon et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15536084	Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase Moon, KD, Durden, DL, Post, CB, De, P, Geahlen, RL, Harrison, ML, Zhou, Q	J Biol Chem	2005
11907067	Syk regulation of phosphoinositide 3-kinase-dependent NK cell function Zhong, B, Wei, S, Jiang, K, Corliss, BC, Gilvary, DL, Vivier, E, Hong-Geller, E, Djeu, JY	J. Immunol.	2002