Reactome | Release of p-PLCG1

Release of p-PLCG1

Stable Identifier

R-HSA-2424485

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Activated PLC-gamma1 disassociates from LAT. Membrane binding is crucial for PLC-gamma 1 activity. The PH-domain of PLC-gamma 1 binds to phosphatidylinositol 3,4,5-trisphosphate [PdtIns(3,4,5)P3], and is targeted to the membrane (Todderud et al. 1990, Wang & Wang. 2003, Kim et al. 2000). Activated PLCG1 then hydrolyses PIP2 to Inositol 1,4,5-triphosphate (IP3) and DAG

Literature References

PubMed ID	Title	Journal	Year
11048639	The mechanism of phospholipase C-gamma1 regulation Suh, PG, Kim, MJ, Kim, E, Ryu, SH	Exp Mol Med	2000
2374928	Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor Carpenter, G, Todderud, G, Rhee, SG, Wahl, MI	Science	1990
12911816	Regulation of EGF-induced phospholipase C-gamma1 translocation and activation by its SH2 and PH domains Wang, Z, Wang, Y	Traffic	2003