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Laminins:Nidogens binds collagen type IV networks
Stable Identifier
R-HSA-2426450
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Extracellular matrix organization (Homo sapiens)
Laminin interactions (Homo sapiens)
Laminins:Nidogens binds collagen type IV networks (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Laminin-bound nidogens can bind to type IV collagen (Aumailey et al. 1989, 1993, Fox et al. 1991, Reinhardt et al. 1993, Ries et al. 2001, Bechtel et al. 2012).
Basement membrane formation involves self-assembly of laminin and of collagen IV into two independent networks (Yurchenco & Schittny 1990, Timpl & Brown 1996) that are connected by nidogen (Fox et al. 1991, Aumailley & Smyth 1998, Aumailey et al. 2000) and the heparan sulfate chains of both perlecan and agrin (Hohenester & Yurchenko 2013).
Literature References
PubMed ID
Title
Journal
Year
3997977
Binding of laminin to type IV collagen: a morphological study
Yurchenco, PD
,
Tsilibary, EC
,
Furthmayr, H
,
Charonis, AS
J Cell Biol
1985
Participants
Input
Collagen IV [extracellular region]
(Homo sapiens)
Laminins with gamma-1, gamma-3:Nidogens 1,2 [extracellular region]
(Homo sapiens)
Output
Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network [extracellular region]
(Homo sapiens)
Participates
as an event of
Laminin interactions (Homo sapiens)
Orthologous Events
Laminins:Nidogens binds collagen type IV networks (Bos taurus)
Laminins:Nidogens binds collagen type IV networks (Canis familiaris)
Laminins:Nidogens binds collagen type IV networks (Mus musculus)
Laminins:Nidogens binds collagen type IV networks (Rattus norvegicus)
Laminins:Nidogens binds collagen type IV networks (Sus scrofa)
Authored
Jupe, S (2012-08-08)
Reviewed
Humphries, MJ (2008-05-07)
Yamada, KM (2008-05-07)
Hynes, R (2008-05-07)
Ricard-Blum, S (2013-08-13)
Created
Jupe, S (2012-08-03)
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