Reactome | APOE [early endosome]

APOE [early endosome]

Stable Identifier

R-HSA-2429687

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome

Synonyms

apoE, apolipoprotein E

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02649 APOE

Gene Names

APOE

Chain

signal peptide:1-18, chain:19-317

Reference Genes

BioGPS Gene:348 APOE

COSMIC (genes):APOE APOE

CTD Gene:348 APOE

dbSNP Gene:348 APOE

ENSEMBL:ENSG00000130203 APOE

ENSEMBL_homo_sapiens_GENE:ENSG00000130203.10 APOE

HGNC:613 APOE

KEGG Gene (Homo sapiens):348 APOE

Monarch:348 APOE

NCBI Gene:348 APOE

OMIM:107741 APOE

UCSC:P02649 APOE

Reference Transcript

Other Identifiers

11744068_x_at

16863115

203381_PM_s_at

203381_s_at

203382_PM_s_at

203382_s_at

212884_PM_x_at

212884_x_at

348

3835880

3835883

3835884

3835886

3835887

3835888

3835889

3835890

608_at

8029530

A_14_P133396

A_23_P164650

A_33_P3223592

GE80881

GO:0000302

GO:0001540

GO:0001937

GO:0002021

GO:0002376

GO:0003013

GO:0005102

GO:0005198

GO:0005215

GO:0005319

GO:0005515

GO:0005543

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005771

GO:0005783

GO:0005788

GO:0005794

GO:0005886

GO:0006351

GO:0006355

GO:0006629

GO:0006641

GO:0006707

GO:0006869

GO:0006874

GO:0006898

GO:0006954

GO:0006979

GO:0007010

GO:0007186

GO:0007263

GO:0007271

GO:0007616

GO:0008092

GO:0008201

GO:0008202

GO:0008203

GO:0008289

GO:0010467

GO:0010468

GO:0010544

GO:0010596

GO:0010629

GO:0010875

GO:0010877

GO:0010976

GO:0010977

GO:0012501

GO:0015909

GO:0016020

GO:0016192

GO:0016209

GO:0017038

GO:0019068

GO:0019899

GO:0019934

GO:0023052

GO:0030154

GO:0030163

GO:0030195

GO:0030312

GO:0030425

GO:0030516

GO:0030669

GO:0031012

GO:0031175

GO:0031410

GO:0031982

GO:0032438

GO:0032489

GO:0032805

GO:0033344

GO:0033700

GO:0034330

GO:0034360

GO:0034361

GO:0034362

GO:0034363

GO:0034364

GO:0034365

GO:0034372

GO:0034374

GO:0034375

GO:0034380

GO:0034382

GO:0034384

GO:0034447

GO:0035641

GO:0036211

GO:0042060

GO:0042157

GO:0042158

GO:0042159

GO:0042311

GO:0042470

GO:0042627

GO:0042632

GO:0042802

GO:0042803

GO:0042981

GO:0042982

GO:0043025

GO:0043083

GO:0043226

GO:0043254

GO:0043395

GO:0043407

GO:0043524

GO:0043537

GO:0043691

GO:0044794

GO:0044877

GO:0045088

GO:0045541

GO:0045807

GO:0045893

GO:0046889

GO:0046907

GO:0046911

GO:0046983

GO:0048156

GO:0048168

GO:0048662

GO:0048844

GO:0048856

GO:0048870

GO:0050709

GO:0050728

GO:0050750

GO:0050807

GO:0050877

GO:0051000

GO:0051044

GO:0051246

GO:0051248

GO:0051651

GO:0055065

GO:0055088

GO:0055089

GO:0060228

GO:0060999

GO:0061024

GO:0061136

GO:0061771

GO:0062023

GO:0065003

GO:0070062

GO:0070326

GO:0070328

GO:0070374

GO:0071682

GO:0071813

GO:0071830

GO:0071831

GO:0072359

GO:0072562

GO:0090090

GO:0090181

GO:0090205

GO:0090209

GO:0097006

GO:0097113

GO:0097114

GO:0097487

GO:0098542

GO:0098754

GO:0098772

GO:0098869

GO:0098978

GO:0120009

GO:0120020

GO:1900221

GO:1900223

GO:1900272

GO:1902430

GO:1902952

GO:1902991

GO:1902995

GO:1903002

GO:1903561

GO:1905860

GO:1905890

GO:1905906

GO:1905907

GO:1905908

GO:1905920

GO:1990777

GO:2000822

HMNXSV003039072

Hs.169401.0.S1_3p_a_at

ILMN_1740938

M12529_at

PH_hs_0022287

TC19000633.hg

g4557324_3p_a_at

Participates

as an output of

NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)

as a component of

Other forms of this molecule

APOE [endosome lumen]

APOE [endosome membrane]

APOE [clathrin-coated endocytic vesicle membrane]

APOE [plasma membrane]

APOE-4 [extracellular region]

APOE [endocytic vesicle lumen]

APOE [extracellular region]

p-APOE [endoplasmic reticulum lumen]

APOE [endoplasmic reticulum lumen]

Inferred To

APOE [early endosome] (Bos taurus)

APOE [early endosome] (Canis familiaris)

APOE [early endosome] (Mus musculus)

APOE [early endosome] (Rattus norvegicus)

APOE [early endosome] (Sus scrofa)

Cross References

RefSeq

NP_001289617.1, NP_001289618.1, NP_001289620.1, NP_000032.1, NP_001289619.1

OpenTargets

ENSG00000130203

HPA

ENSG00000130203-APOE

GeneCards

P02649

Ensembl

ENST00000252486, ENSG00000130203, ENSP00000252486

PRO

P02649

Pharos - Targets

P02649

Orphanet

15940

HMDB Protein

HMDBP01986

PDB

1LPE, 7FCR, 1EA8, 7FCS, 1BZ4, 1GS9, 2KNY, 2L7B, 2KC3, 1H7I, 1NFO, 1NFN, 6NCN, 8AX8, 1OR3, 8CE0, 7UVJ, 6NCO, 1LE4, 1B68, 1OR2, 8CDY, 8GRX, 8AX9, 1OEG, 6IWB, 1LE2, 1OEF

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.809	11
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.784	23
UniProt:P05067-PRO_0000000093 APP			0.75	4
ChEBI:28304 HEPARIN			0.733	8
UniProt:P01130 LDLR	4	LDLR [endolysosome membrane] (R-HSA-6784818) LDLR [endosome membrane] (R-HSA-171127) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [plasma membrane] (R-HSA-171053)	0.71	4
UniProt:P00738 HP	7	HP [specific granule lumen] (R-HSA-6799622) HP [extracellular region] (R-HSA-6799677) HP [tertiary granule lumen] (R-HSA-6800879) 5xHC-HP(162-406) [endocytic vesicle lumen] (R-HSA-2230973) 7xHC-HP(19-160) [endocytic vesicle lumen] (R-HSA-2230994) 5xHC-HP(162-406) [extracellular region] (R-HSA-2168875) 7xHC-HP(19-160) [extracellular region] (R-HSA-2168848)	0.675	7
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.672	8
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.641	9
UniProt:Q9NZC2 TREM2	1	TREM2 [plasma membrane] (R-HSA-197664)	0.602	4
UniProt:O75069 TMCC2			0.593	5
ChEBI:241349 DIMYRISTOYLPHOSPHATIDYL CHOLINE			0.59	3
UniProt:P21796 VDAC1	7	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991)	0.589	2
UniProt:P02748 C9	1	C9(22-559) [extracellular region] (R-HSA-173717)	0.564	2
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.556	3
UniProt:Q9HBG4 ATP6V0A4	2	ATP6V0A4 [phagocytic vesicle membrane] (R-HSA-1222302) ATP6V0A4 [endosome membrane] (R-HSA-912605)	0.556	3
UniProt:P11137-4 MAP2			0.556	3
UniProt:P02795 MT2A	1	MT2A [cytosol] (R-HSA-1031707)	0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P26441 CNTF	1	CNTF [extracellular region] (R-HSA-5696441)	0.556	3
UniProt:Q3SYB3 FX4L6			0.556	3
UniProt:Q9NUB4 CT141			0.556	3
UniProt:Q6PID6 TTC33			0.556	3
UniProt:P10636-6 MAPT			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
UniProt:Q8IUW6 Q8IUW6			0.556	3
IntAct:EBI-25832170 ORF			0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:Q14114-3 Q141143			0.556	3
UniProt:Q9NS23-4 RASSF1			0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:Q9Y6C2-2 EMILIN1			0.556	3
UniProt:Q9NYH9 UTP6	1	UTP6 [nucleoplasm] (R-HSA-6790674)	0.556	3
UniProt:Q9H6J7-2 CSTPP1			0.556	3
UniProt:P17028 ZNF24			0.556	3
UniProt:P09382 LGALS1	2	p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003) LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711)	0.556	3
IntAct:EBI-25832355 CCSB			0.556	3
UniProt:Q8IY40 Q8IY40			0.556	3
UniProt:O75409 HYPM			0.556	3
UniProt:Q9H816 DCLRE1B	1	DCLRE1B [nucleoplasm] (R-HSA-6785735)	0.556	3
UniProt:Q8WTV0-2 SCARB1	2	SCARB1-2 [endocytic vesicle membrane] (R-HSA-2512788) SCARB1-2 [plasma membrane] (R-HSA-349415)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:Q9UIJ7 AK3	1	AK3 [mitochondrial matrix] (R-HSA-1008241)	0.556	3
UniProt:P27958-PRO_0000037570			0.537	4
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	7
UniProt:P02655 APOC2	3	APOC2 [early endosome] (R-HSA-2429686) APOC2 [cytosol] (R-HSA-2404145) APOC2 [extracellular region] (R-HSA-174699)	0.527	2
UniProt:P08254 MMP3	6	MMP3(55-99) [extracellular region] (R-HSA-1604687) MMP3(18-54) [extracellular region] (R-HSA-1604705) MMP3(55-477) [extracellular region] (R-HSA-1604735) MMP3(18-477) [extracellular region] (R-HSA-1604707) MMP3 [extracellular region] (R-HSA-8943665) MMP3(100-477) [extracellular region] (R-HSA-1430778)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:Q13201 MMRN1	2	MMRN1(20-1228) [extracellular region] (R-HSA-114635) MMRN1(20-1228) [platelet alpha granule lumen] (R-HSA-114634)	0.527	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586)	0.527	2
UniProt:P09238 MMP10	2	MMP10 [extracellular region] (R-HSA-1442488) MMP10(18-476) [extracellular region] (R-HSA-1604748)	0.527	2
UniProt:Q9UBD9 CLCF1	1	CLCF1 [extracellular region] (R-HSA-5693175)	0.524	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.524	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.482	3
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.482	3
UniProt:P50502 ST13	1	ST13 [cytosol] (R-HSA-5255410)	0.482	3

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