Reactome | p-Y397-LYN [plasma membrane]

p-Y397-LYN [plasma membrane]

Stable Identifier

R-HSA-2454229

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

LYN_HUMAN, LYN

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Locations in the PathwayBrowser for interactor UniProt:Q9NWQ8 PAG1

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External Reference Information

External Reference

UniProt:P07948 LYN

Gene Names

LYN, JTK8

Chain

initiator methionine:, chain:2-512

Reference Genes

BioGPS Gene:4067 LYN

COSMIC (genes):LYN LYN

CTD Gene:4067 LYN

dbSNP Gene:4067 LYN

ENSEMBL:ENSG00000254087 LYN

ENSEMBL_homo_sapiens_GENE:ENSG00000254087.8 LYN

HGNC:6735 LYN

KEGG Gene (Homo sapiens):4067 LYN

Monarch:4067 LYN

NCBI Gene:4067 LYN

OMIM:165120 LYN

UCSC:P07948 LYN

Reference Transcript

Other Identifiers

11718084_a_at

11718085_s_at

11732514_s_at

1402_at

17069063

2024_s_at

202625_PM_at

202625_at

202626_PM_s_at

202626_s_at

210754_PM_s_at

210754_s_at

3098978

3098979

3098997

3098998

3098999

3099000

3099001

3099002

3099005

3099006

3099007

3099010

3099011

3099024

3099026

3099028

3099029

3099030

3099050

32616_at

4067

54933_at

77231_at

8146500

A_14_P123503

A_23_P147431

GE57840

GO:0000077

GO:0000166

GO:0001782

GO:0001817

GO:0001932

GO:0001933

GO:0001934

GO:0002223

GO:0002244

GO:0002250

GO:0002376

GO:0002431

GO:0002513

GO:0002553

GO:0002576

GO:0002762

GO:0002768

GO:0002774

GO:0002862

GO:0002902

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005161

GO:0005178

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005764

GO:0005765

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0005912

GO:0006468

GO:0006954

GO:0006974

GO:0006991

GO:0007155

GO:0007165

GO:0007169

GO:0008092

GO:0008284

GO:0008285

GO:0008289

GO:0009410

GO:0009636

GO:0009725

GO:0009743

GO:0009898

GO:0009986

GO:0010976

GO:0012501

GO:0014003

GO:0014070

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0017124

GO:0018108

GO:0019899

GO:0023052

GO:0030061

GO:0030097

GO:0030154

GO:0030218

GO:0030222

GO:0030335

GO:0030666

GO:0030889

GO:0031175

GO:0031234

GO:0031295

GO:0031410

GO:0031625

GO:0031663

GO:0031668

GO:0031966

GO:0032868

GO:0032991

GO:0033003

GO:0033628

GO:0034136

GO:0034142

GO:0034144

GO:0034605

GO:0034666

GO:0035556

GO:0036211

GO:0038043

GO:0038095

GO:0038096

GO:0038159

GO:0042060

GO:0042327

GO:0042531

GO:0043015

GO:0043200

GO:0043208

GO:0043226

GO:0043231

GO:0043304

GO:0043407

GO:0043410

GO:0043434

GO:0044325

GO:0044877

GO:0045087

GO:0045121

GO:0045646

GO:0046777

GO:0046875

GO:0048013

GO:0048471

GO:0048678

GO:0048856

GO:0048870

GO:0050727

GO:0050777

GO:0050853

GO:0050855

GO:0050900

GO:0051219

GO:0051279

GO:0055065

GO:0055085

GO:0060252

GO:0060369

GO:0060397

GO:0070062

GO:0070372

GO:0070373

GO:0070447

GO:0070667

GO:0070668

GO:0071300

GO:0090025

GO:0090330

GO:0097028

GO:0097110

GO:0098542

GO:0098978

GO:0099091

GO:0140031

GO:0140096

GO:0141038

GO:1902532

GO:1902961

GO:2000670

HMNXSV003009154

Hs.80887.0.A2_3p_at

ILMN_1781155

M16038_at

PH_hs_0004647

TC08000383.hg

g187270_3p_a_at

g4505054_3p_a_at

Participates

as an output of

Autophosphorylation of LYN kinase (Homo sapiens)

as an input of

Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)

as a member of

SYK/p-LYN [plasma membrane] (Homo sapiens)

as a component of

p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)

Other forms of this molecule

MyrG2-PalmC3-LYN [lysosomal membrane]

MyrG2-PalmC3-LYN [endocytic vesicle membrane]

LYN [plasma membrane]

p-Y397-LYN [cytosol]

MyrG2-PalmC3-LYN [plasma membrane]

LYN [cytosol]

Inferred To

phospho-LYN [plasma membrane] (Bos taurus)

phospho-p-Y397-LYN [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y397-LYN [plasma membrane] (Canis familiaris)

phospho-p-Y397-LYN [plasma membrane] (Drosophila melanogaster)

phospho-p-Y397-LYN [plasma membrane] (Gallus gallus)

phospho-p-Y397-LYN [plasma membrane] (Mus musculus)

phospho-p-Y397-LYN [plasma membrane] (Rattus norvegicus)

phospho-p-Y397-LYN [plasma membrane] (Sus scrofa)

phospho-p-Y397-LYN [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001104567.1, XP_016868905.1, NP_002341.1

ZINC - World Drugs

LYN_HUMAN

Guide to Pharmacology - Targets

2060

OpenTargets

ENSG00000254087

ZINC - FDA approved

LYN_HUMAN

ZINC - Substances

LYN_HUMAN

ZINC target

P07948

ZINC - Biogenic

LYN_HUMAN

PRO

P07948

PDB

1W1F, 6NMW, 3A4O, 8WFF, 5XY1, 1WA7

ZINC - Investigational

LYN_HUMAN

IntEnz

2.7.10.2

GeneCards

P07948

HPA

ENSG00000254087-LYN

Ensembl

ENSP00000428424, ENSP00000428924, ENST00000520220, ENST00000519728, ENSG00000254087

Pharos - Targets

P07948

ZINC - Predictions - Purchasable

LYN_HUMAN

HMDB Protein

HMDBP13811

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.82	7
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.704	4
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.669	4
UniProt:Q9WMX2 POLG			0.667	3
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.641	16
UniProt:Q9HCN6 GP6	1	GP6 [plasma membrane] (R-HSA-114574)	0.641	5
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.609	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.609	2
UniProt:Q8NDB2 BANK1			0.591	3
UniProt:O92972 POLG			0.589	2
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.573	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P22575 TIP			0.558	3
UniProt:Q8R5G7	1	Arap3 [cytosol] (R-MMU-195185)	0.558	2
UniProt:O43184 ADAM12	1	ADAM12 [plasma membrane] (R-HSA-179792)	0.558	2
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.556	3
UniProt:Q96GW7 BCAN	20	D2,4,4(S)3-BCAN(361-911) [extracellular region] (R-HSA-3791190) CSE-BCAN(361-911) [extracellular region] (R-HSA-3791188) C6S-BCAN(361-911) [extracellular region] (R-HSA-3791186) C4S-BCAN(361-911) [extracellular region] (R-HSA-3791182) D2,4(S)2-BCAN(361-911) [extracellular region] (R-HSA-3791181) D4S-BCAN(361-911) [extracellular region] (R-HSA-3791193) D4S-BCAN(23-360) [extracellular region] (R-HSA-3791191) D2,4(S)2-BCAN(23-360) [extracellular region] (R-HSA-3791189) C6S-BCAN(23-360) [extracellular region] (R-HSA-3791184) D2,4,4(S)3-BCAN(23-360) [extracellular region] (R-HSA-3791180) C4S-BCAN(23-360) [extracellular region] (R-HSA-3791179) CSE-BCAN(23-360) [extracellular region] (R-HSA-3791192) D2,4(S)2-BCAN(23-395) [extracellular region] (R-HSA-3791174) D2,4,4(S)3-BCAN(23-395) [extracellular region] (R-HSA-3791127) C6S-BCAN(23-395) [extracellular region] (R-HSA-3791162) C4S-BCAN(23-395) [extracellular region] (R-HSA-3791130) D4S-BCAN(23-395) [extracellular region] (R-HSA-3791147) CSE-BCAN(23-395) [extracellular region] (R-HSA-3791131) C4S-BCAN(396-911) [extracellular region] (R-HSA-3791157) D2,4,4(S)3-BCAN(396-911) [extracellular region] (R-HSA-3791170)	0.556	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:P07602 PSAP	11	PSAP(60-142) [extracellular region] (R-HSA-351338) PSAP(17-524) [plasma membrane] (R-HSA-6806262) PSAP(17-524) [azurophil granule membrane] (R-HSA-6799212) PSAP(311-391) [lysosomal lumen] (R-HSA-9851355) PSAP(405-486) [lysosomal lumen] (R-HSA-9840328) PSAP(311-391) [lysosomal membrane] (R-HSA-1605602) PSAP(60-142) [lysosomal lumen] (R-HSA-351333) PSAP [lysosomal lumen] (R-HSA-9840325) PSAP(195-273) [lysosomal lumen] (R-HSA-9840336) PSAP(?-?) [extracellular region] (R-HSA-5336190) PSAP(326-340) [extracellular region] (R-HSA-5336179)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.556	3
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.544	2
UniProt:O95684 CEP43	3	FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604533) FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838994) FGFR1OP [cytosol] (R-HSA-380309)	0.527	2
UniProt:Q9NQW6 ANLN	1	ANLN [cytosol] (R-HSA-9690261)	0.527	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.527	2
UniProt:P09769 FGR	3	FGR [extracellular region] (R-HSA-6806524) FGR [secretory granule lumen] (R-HSA-6804974) FGR [cytosol] (R-HSA-432116)	0.527	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.527	3
UniProt:Q9HCN6-1 GP6			0.524	2
UniProt:Q15642 TRIP10	1	TRIP10 [cytosol] (R-HSA-195120)	0.508	2
UniProt:P16671 CD36	5	CD36 [platelet alpha granule membrane] (R-HSA-114687) 4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151) CD36 [phagocytic vesicle] (R-HSA-1236835) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) 4xPalmC-CD36 [plasma membrane] (R-HSA-51645)	0.499	3
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.499	4
UniProt:Q6UWF3 SCIMP			0.499	3
UniProt:Q08857 Cd36	6	Cd36 [platelet alpha granule membrane] (R-MMU-114687) Cd36 [specific granule membrane] (R-MMU-6806151) Cd36 [phagocytic vesicle] (R-MMU-1236835) Cd36 [endocytic vesicle membrane] (R-MMU-2239449) Cd36 [plasma membrane] (R-MMU-51645) Cd36 [plasma membrane] (R-MMU-2187219)	0.499	2
UniProt:P11049 CD37			0.499	5
UniProt:P14317 HCLS1			0.499	2
UniProt:P20273 CD22	3	NAc-CD22 [plasma membrane] (R-HSA-5690736) CD22 [plasma membrane] (R-HSA-197703) p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726)	0.499	2
UniProt:P25063 CD24	1	CD24(29-534) [plasma membrane] (R-HSA-430062)	0.499	6
UniProt:P61980	2	Hnrnpk [nucleoplasm] (R-RNO-4570532) Hnrnpk [nucleoplasm] (R-RNO-71945)	0.469	2

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