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SAA1(19-122) [extracellular region]
Stable Identifier
R-HSA-2457833
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
SAA1, Serum amyloid A protein 1 alpha, Serum amyloid A-1 protein, SAA1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Advanced glycosylation endproduct receptor signaling (Homo sapiens)
AGER binds ERK1/2 (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
AGER ligands:AGER:ERK [plasma membrane] (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
FPR2 binds FPR2 ligands (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class B Receptors (Homo sapiens)
SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
SCARB1:Ligand [plasma membrane] (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
SCARB1:ligand is endocytosed (Homo sapiens)
SCARB1:Endocytosed Ligand [plasma membrane] (Homo sapiens)
Endocytosed Ligands of SCARB1 [extracellular region] (Homo sapiens)
SAA1(19-122) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0DJI8 SAA1
Gene Names
SAA1
Chain
signal peptide:1-18, chain:19-122, chain:19-94, chain:20-122, chain:20-121, chain:20-120, chain:21-122, chain:22-119, propeptide:95-122
Reference Genes
BioGPS Gene:6288 SAA1
COSMIC (genes):SAA1 SAA1
CTD Gene:6288 SAA1
dbSNP Gene:6288 SAA1
ENSEMBL:ENSG00000173432 SAA1
ENSEMBL_homo_sapiens_GENE:ENSG00000173432.13 SAA1
HGNC:10513 SAA1
KEGG Gene (Homo sapiens):6288 SAA1
Monarch:6288 SAA1
NCBI Gene:6288 SAA1
OMIM:104750 SAA1
UCSC:P0DJI8 SAA1
Reference Transcript
RefSeq:NM_199161.4 SAA1
RefSeq:NM_000331.5 SAA1
RefSeq:NM_001178006.2 SAA1
Other Identifiers
11733442_x_at
11756072_s_at
16722562
208607_3p_s_at
208607_PM_s_at
208607_s_at
214456_PM_x_at
214456_x_at
3322701
3322702
3322703
3322705
3322708
3322709
3322710
33272_at
3365339
3365342
3365345
3365346
3365347
6288
7938758
7946986
8180303
GE57890
GO:0001664
GO:0001819
GO:0002376
GO:0005576
GO:0005615
GO:0005856
GO:0005881
GO:0006953
GO:0006954
GO:0007155
GO:0007204
GO:0008201
GO:0030168
GO:0030593
GO:0031410
GO:0032732
GO:0034364
GO:0042060
GO:0043226
GO:0045785
GO:0048246
GO:0048247
GO:0048870
GO:0050708
GO:0050728
GO:0070062
GO:0071682
HMNXSV003010243
HMNXSV003011903
ILMN_1701017
ILMN_1808732
ILMN_2304512
J03474_at
TC11000238.hg
TC11002587.hg
X51441_at
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
Endocytosed Ligands of SCARB1 [extracellular region] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
Other forms of this molecule
SAA1(19-122) [endocytic vesicle lumen]
SAA1(19-94) [extracellular region]
Cross References
RefSeq
NP_954630.1
,
NP_000322.2
,
NP_001171477.1
OpenTargets
ENSG00000173432
GeneCards
P0DJI8
HPA
ENSG00000173432-SAA1
Ensembl
ENSP00000348918
,
ENSP00000384906
,
ENST00000356524
,
ENSG00000173432
,
ENST00000405158
PRO
P0DJI8
Pharos - Targets
P0DJI8
Orphanet
21972
PDB
4IP8
,
6MST
,
4IP9
,
7ZKY
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