Reactome | RAD21 [chromosome, centromeric region]

RAD21 [chromosome, centromeric region]

Stable Identifier

R-HSA-2466012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome, centromeric region

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        RAD21 [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        RAD21 [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        RAD21 [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        RAD21 [chromosome, centromeric region] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        RAD21 [chromosome, centromeric region] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Establishment of Sister Chromatid Cohesion (Homo sapiens)
      - CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        RAD21 [chromosome, centromeric region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60216 RAD21

Gene Names

RAD21, HR21, KIAA0078, NXP1, SCC1

Chain

chain:1-631, chain:280-631

Reference Genes

BioGPS Gene:5885 RAD21

COSMIC (genes):RAD21 RAD21

CTD Gene:5885 RAD21

dbSNP Gene:5885 RAD21

ENSEMBL:ENSG00000164754 RAD21

ENSEMBL_homo_sapiens_GENE:ENSG00000164754.16 RAD21

HGNC:9811 RAD21

KEGG Gene (Homo sapiens):5885 RAD21

Monarch:5885 RAD21

NCBI Gene:5885 RAD21

OMIM:606462 RAD21

UCSC:O60216 RAD21

Reference Transcript

RefSeq:NM_006265.2 RAD21

Other Identifiers

11716436_s_at

11716437_a_at

11716438_at

11754303_s_at

17080408

200607_PM_s_at

200607_s_at

200608_PM_s_at

200608_s_at

3149849

3149850

3149852

3149855

3149857

3149858

3149861

3149862

3149863

3149864

3149865

3149866

3149869

3149871

3149873

3149880

3149881

3149882

3149883

38114_at

3984533

3984537

5885

8152477

D38551_at

GE57195

GO:0000228

GO:0000278

GO:0000775

GO:0000785

GO:0000794

GO:0000922

GO:0001666

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0006281

GO:0006302

GO:0006310

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006915

GO:0006974

GO:0007049

GO:0007059

GO:0007062

GO:0007131

GO:0008278

GO:0010628

GO:0010629

GO:0010972

GO:0012501

GO:0016020

GO:0016043

GO:0016363

GO:0022414

GO:0030496

GO:0030892

GO:0030893

GO:0032691

GO:0032720

GO:0032733

GO:0034087

GO:0034089

GO:0034351

GO:0043226

GO:0043524

GO:0045841

GO:0045876

GO:0051301

GO:0071168

GO:0106222

GO:0140013

GO:0140014

GO:0140297

GO:0140588

GO:1990414

HMNXSV003020959

HMNXSV003027934

Hs.81848.0.S1_3p_a_at

PH_hs_0004675

TC08001546.hg

g5453993_3p_a_at

Participates

as a component of

Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K-RAD21 [nucleoplasm]

p-S454-RAD21 [cytosol]

p-S454-RAD21 [chromosome]

RAD21 [cytosol]

p-S454-RAD21(451-631) [cytosol]

RAD21(173-450) [cytosol]

RAD21(1-172) [cytosol]

RAD21(173-450) [chromosome, centromeric region]

p-S454-RAD21(451-631) [chromosome, centromeric region]

RAD21(1-172) [chromosome, centromeric region]

p-S454-RAD21 [chromosome, centromeric region]

RAD21 [chromosome]

RAD21 [nucleoplasm]

Inferred To

coh-1 [chromosome, centromeric region] (Caenorhabditis elegans)

rad21 [chromosome, centromeric region] (Schizosaccharomyces pombe)

MCD1 [chromosome, centromeric region] (Saccharomyces cerevisiae)

rad21b [chromosome, centromeric region] (Danio rerio)

rec8 [chromosome, centromeric region] (Schizosaccharomyces pombe)

rec-8 [chromosome, centromeric region] (Caenorhabditis elegans)

Ghost homologue of RAD21 [chromosome, centromeric region] (Xenopus tropicalis)

Homologues of RAD21 [chromosome, centromeric region] (Caenorhabditis elegans)

Homologues of RAD21 [chromosome, centromeric region] (Saccharomyces cerevisiae)

Homologues of RAD21 [chromosome, centromeric region] (Schizosaccharomyces pombe)

vtd [chromosome, centromeric region] (Drosophila melanogaster)

Rad21 [chromosome, centromeric region] (Mus musculus)

Rad21 [chromosome, centromeric region] (Rattus norvegicus)

scc-1 [chromosome, centromeric region] (Caenorhabditis elegans)

REC8 [chromosome, centromeric region] (Saccharomyces cerevisiae)

RAD21 [chromosome, centromeric region] (Bos taurus)

RAD21 [chromosome, centromeric region] (Canis familiaris)

RAD21 [chromosome, centromeric region] (Dictyostelium discoideum)

RAD21 [chromosome, centromeric region] (Gallus gallus)

RAD21 [chromosome, centromeric region] (Sus scrofa)

Cross References

RefSeq

NP_006256.1

OpenTargets

ENSG00000164754

GeneCards

O60216

HPA

ENSG00000164754-RAD21

Ensembl

ENSG00000164754, ENST00000522699, ENSP00000509687, ENST00000687358, ENST00000520992, ENST00000297338, ENSP00000430524, ENST00000517749, ENST00000519837, ENSP00000430273, ENSP00000297338, ENSP00000429342, ENSP00000428158, ENST00000517485, ENSP00000427923

PRO

O60216

Pharos - Targets

O60216

Orphanet

21189

PDB

6WG3, 4PK7, 4PJU, 7W1M, 6WGE, 4PJW, 7ZJS, 6QNX, 6RRK, 6RRC

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N3U4 STAG2	8	monoSUMO1-K-STAG2 [nucleoplasm] (R-HSA-3108187) p-STAG2 [chromosome, centromeric region] (R-HSA-2466013) p-STAG2 [cytosol] (R-HSA-2484806) p-STAG2 [chromosome] (R-HSA-1638793) STAG2 [cytosol] (R-HSA-2484897) STAG2 [chromosome] (R-HSA-1638777) STAG2 [chromosome, centromeric region] (R-HSA-2466018) STAG2 [nucleoplasm] (R-HSA-163046)	0.966	22
UniProt:Q9UQE7 SMC3	6	SMC3 [cytosol] (R-HSA-2545223) 2xAcK-SMC3 [cytosol] (R-HSA-2484792) 2xAcK-SMC3 [chromosome] (R-HSA-2468146) 2xAcK-SMC3 [chromosome, centromeric region] (R-HSA-2468148) 2xAcK-SMC3 [nucleoplasm] (R-HSA-2468050) SMC3 [nucleoplasm] (R-HSA-163009)	0.956	18
UniProt:Q14683 SMC1A	4	SMC1A [cytosol] (R-HSA-2484798) SMC1A [chromosome] (R-HSA-1638774) SMC1A [chromosome, centromeric region] (R-HSA-2466015) SMC1A [nucleoplasm] (R-HSA-64561)	0.926	18
UniProt:Q8WVM7 STAG1	4	STAG1 [cytosol] (R-HSA-2484793) STAG1 [chromosome] (R-HSA-1638773) STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017)	0.918	12
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.905	18
UniProt:Q29RF7 PDS5A	4	PDS5A [cytosol] (R-HSA-2484799) PDS5A [chromosome] (R-HSA-2466360) PDS5A [chromosome, centromeric region] (R-HSA-2468259) PDS5A [nucleoplasm] (R-HSA-2468043)	0.857	6
UniProt:Q9NTI5 PDS5B	4	PDS5B [cytosol] (R-HSA-2484800) PDS5B [chromosome] (R-HSA-2466361) PDS5B [chromosome, centromeric region] (R-HSA-2468263) PDS5B [nucleoplasm] (R-HSA-2468051)	0.813	5
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.737	6
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.674	9
UniProt:Q9CPY3	6	phospho-Cdca5 [chromosome] (R-MMU-2468266) phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.669	3
UniProt:Q13643 FHL3			0.666	4
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.643	4
UniProt:Q9CW03 Smc3	6	SMC3 [cytosol] (R-MMU-2545223) 2xAcK-SMC3 [cytosol] (R-MMU-2484792) 2xAcK-SMC3 [chromosome] (R-MMU-2468146) 2xAcK-SMC3 [chromosome, centromeric region] (R-MMU-2468148) 2xAcK-SMC3 [nucleoplasm] (R-MMU-2468050) Structural maintenance of chromosomes protein 3 [nucleoplasm] (R-MMU-912387)	0.597	5
UniProt:Q8NFQ8 TOIP2			0.527	2
UniProt:A9IYQ1 A9IYQ1			0.527	2
UniProt:Q9HCH3 CPNE5			0.527	2
UniProt:Q92995 USP13	2	USP13 [nucleoplasm] (R-HSA-6781924) USP13 [cytosol] (R-HSA-6781893)	0.527	2
UniProt:P13497 BMP1	1	BMP1 [extracellular region] (R-HSA-2002393)	0.527	2
UniProt:Q9NTI5-2 PDS5B			0.527	2
UniProt:Q8N3U4-2 STAG2			0.527	2
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.527	2
UniProt:Q9BSQ5 CCM2			0.527	2
UniProt:Q96K76 USP47	1	USP47 [nucleoplasm] (R-HSA-5696961)	0.527	2
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.527	2

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