Reactome | STAG2 [chromosome, centromeric region]

STAG2 [chromosome, centromeric region]

Stable Identifier

R-HSA-2466018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome, centromeric region

Synonyms

SA2

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Cleaved Cohesin [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Cleaved Cohesin [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Establishment of Sister Chromatid Cohesion (Homo sapiens)
      - CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Homo sapiens)
        
        STAG2 [chromosome, centromeric region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N3U4 STAG2

Gene Names

STAG2, SA2

Chain

chain:1-1231

Reference Genes

BioGPS Gene:10735 STAG2

COSMIC (genes):STAG2 STAG2

CTD Gene:10735 STAG2

dbSNP Gene:10735 STAG2

ENSEMBL:ENSG00000101972 STAG2

ENSEMBL:ENSG00000101972.20 STAG2

HGNC:11355 STAG2

KEGG Gene (Homo sapiens):10735 STAG2

Monarch:10735 STAG2

NCBI Gene:10735 STAG2

OMIM:300826 STAG2

UCSC:Q8N3U4 STAG2

Reference Transcript

Other Identifiers

10735

11731107_a_at

11731108_s_at

11739903_a_at

11743520_a_at

17106739

207983_PM_s_at

207983_s_at

209022_PM_at

209022_at

209023_PM_s_at

209023_s_at

34709_r_at

3989716

3989717

3989718

3989720

3989722

3989723

3989724

3989726

3989727

3989728

3989731

3989748

3989749

3989750

3989751

3989753

3989755

3989756

3989757

3989759

3989761

3989762

3989763

3989764

3989765

3989766

3989767

3989768

3989769

3989770

3989771

3989773

3989774

3989775

3989776

3989779

3989780

3989781

3989782

3989783

3989784

3989785

3989787

3989788

3989792

3989793

3989797

3989798

3989799

48629_s_at

48630_r_at

64266_at

8169750

A_24_P66125

A_33_P3304293

GE528843

GE85697

GO:0000278

GO:0000775

GO:0000785

GO:0001650

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005829

GO:0005856

GO:0007010

GO:0007049

GO:0007059

GO:0007062

GO:0008278

GO:0016020

GO:0016363

GO:0022414

GO:0034087

GO:0043226

GO:0051301

GO:0051321

GO:0090307

GO:0097431

GO:0140014

HMNXSV003015521

Hs.8217.1.A2_3p_at

ILMN_1782609

ILMN_2293677

ILMN_2333708

PH_hs_0000880

TC0X000606.hg

TC0X001859.hg

g5730068_3p_a_at

Participates

as a component of

Other forms of this molecule

monoSUMO1-K-STAG2 [nucleoplasm]

p-STAG2 [cytosol]

p-STAG2 [chromosome]

p-STAG2 [chromosome, centromeric region]

STAG2 [cytosol]

STAG2 [chromosome]

STAG2 [nucleoplasm]

Inferred To

IRR1 [chromosome, centromeric region] (Saccharomyces cerevisiae)

STAG2 [chromosome, centromeric region] (Bos taurus)

STAG2 [chromosome, centromeric region] (Canis familiaris)

STAG2 [chromosome, centromeric region] (Danio rerio)

STAG2 [chromosome, centromeric region] (Dictyostelium discoideum)

STAG2 [chromosome, centromeric region] (Gallus gallus)

STAG2 [chromosome, centromeric region] (Sus scrofa)

SA1 [chromosome, centromeric region] (Drosophila melanogaster)

scc-3 [chromosome, centromeric region] (Caenorhabditis elegans)

stag2 [chromosome, centromeric region] (Xenopus tropicalis)

Stag2 [chromosome, centromeric region] (Mus musculus)

Stag2 [chromosome, centromeric region] (Rattus norvegicus)

psc3 [chromosome, centromeric region] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001036214.1, NP_001269347.1, XP_005262416.1, XP_016884721.1, NP_001036216.1, XP_005262417.1, XP_016884722.1, NP_001036215.1, NP_006594.3, XP_005262418.1, XP_006724790.1, XP_016884723.1, XP_011529555.1, XP_005262414.1, XP_005262415.1

OpenTargets

ENSG00000101972

HPA

ENSG00000101972-STAG2

GeneCards

Q8N3U4

Ensembl

ENST00000371160, ENSP00000360186, ENSP00000360187, ENSP00000360199, ENST00000218089, ENST00000687852, ENST00000371157, ENST00000371145, ENST00000371144, ENSP00000218089, ENSG00000101972, ENSP00000360202, ENSP00000509048

PRO

Q8N3U4

Pharos - Targets

Q8N3U4

Orphanet

24951

PDB

4PJW, 4PK7, 4PJU, 6QNX

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21 [cytosol] (R-HSA-2484795) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21(173-450) [cytosol] (R-HSA-2500308) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775)	0.962	19
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.893	13
UniProt:Q9CPY3	6	phospho-Cdca5 [chromosome] (R-MMU-2468266) phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.669	3
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.577	4