NRPE dissociates to atRAL and PE

Stable Identifier
R-HSA-2466718
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, photoreceptor outer segment membrane
ReviewStatus
5/5
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NRPE dissociates to atRAL and PE
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Once NRPE is "flipped" to the cytoplasmic side of disc membranes by the ABC transporter ABCA4, it can dissociate to all-trans-retinal (atRAL) and phosphatidylethanolamine (PE). atRAL is thus released to re-enter the retinoid cycle to reform the visual chromophore 11-cis-retinal (11cRAL) (Tsybovsky et al. 2010).
Literature References
PubMed ID Title Journal Year
20711710 The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease

Palczewski, K, Molday, RS, Tsybovsky, Y

Adv. Exp. Med. Biol. 2010
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as an event of
Authored
Jassal, B  (2012-09-12)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-09-12)
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