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PDS5A [nucleoplasm]
Stable Identifier
R-HSA-2468043
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Sister chromatid cohesion protein PDS5 homolog A, PDS5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Telophase/Cytokinesis (Homo sapiens)
Cohesin Loading onto Chromatin (Homo sapiens)
Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Homo sapiens)
Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL:NIPBL:MAU2:Centromere [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromosomal Arm [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
Cohesin binds PDS5 and WAPAL (Homo sapiens)
Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Establishment of Sister Chromatid Cohesion (Homo sapiens)
Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm [nucleoplasm] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL:Chromosomal Arm [nucleoplasm] (Homo sapiens)
Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm [nucleoplasm] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Homo sapiens)
PDS5 [nucleoplasm] (Homo sapiens)
PDS5A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q29RF7 PDS5A
Gene Names
PDS5A, KIAA0648, PDS5, PIG54
Chain
chain:1-1337
Reference Genes
BioGPS Gene:23244 PDS5A
COSMIC (genes):PDS5A PDS5A
CTD Gene:23244 PDS5A
dbSNP Gene:23244 PDS5A
ENSEMBL:ENSG00000121892 PDS5A
ENSEMBL:ENSG00000121892.15 PDS5A
HGNC:29088 PDS5A
KEGG Gene (Homo sapiens):23244 PDS5A
Monarch:23244 PDS5A
NCBI Gene:23244 PDS5A
OMIM:613200 PDS5A
UCSC:Q29RF7 PDS5A
Reference Transcript
RefSeq:NM_001100400.1 PDS5A
RefSeq:NM_001100399.1 PDS5A
RefSeq:XM_017007928.1 PDS5A
RefSeq:XM_011513672.2 PDS5A
Other Identifiers
11717182_a_at
11717183_a_at
11726842_a_at
11737960_a_at
11764202_at
16975345
212138_PM_at
212138_at
212140_PM_at
212140_at
213983_PM_s_at
213983_s_at
213984_PM_at
213984_at
23244
2766593
2766594
2766595
2766596
2766597
2766598
2766599
2766608
2766609
2766610
2766611
2766614
2766615
2766616
2766620
2766621
2766623
2766624
2766628
2766629
2766631
2766632
2766633
2766634
2766637
2766639
2766642
2766643
2766644
2766645
2766646
2766647
2766648
2766649
2766651
2766652
2766655
2766656
2766658
2766661
2766662
2766664
2766665
2766666
2766667
2766669
2766683
2766684
2766685
2766686
2766687
2766688
2766694
34353_at
74513_at
8099926
A_23_P144294
A_24_P186216
A_24_P52004
GE53359
GE846093
GE85303
GO:0000278
GO:0000775
GO:0000785
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0005886
GO:0006260
GO:0007049
GO:0007059
GO:0007064
GO:0008156
GO:0043226
GO:0051301
GO:0140014
HMNXSV003003914
HMNXSV003004169
Hs.31921.0.S1_3p_at
Hs.31921.0.S1_3p_x_at
Hs.31921.1.S1_3p_at
Hs.31921.1.S2_3p_at
ILMN_1670931
PH_hs_0002712
TC04001134.hg
TC04002521.hg
Participates
as a member of
PDS5 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PDS5A [cytosol]
PDS5A [chromosome]
PDS5A [chromosome, centromeric region]
Inferred To
evl-14 [nucleoplasm]
(Caenorhabditis elegans)
PDS5 [nucleoplasm]
(Saccharomyces cerevisiae)
Pds5a [nucleoplasm]
(Mus musculus)
Pds5a [nucleoplasm]
(Rattus norvegicus)
PDS5A [nucleoplasm]
(Bos taurus)
PDS5A [nucleoplasm]
(Canis familiaris)
PDS5A [nucleoplasm]
(Gallus gallus)
PDS5A [nucleoplasm]
(Sus scrofa)
pds5 [nucleoplasm]
(Dictyostelium discoideum)
pds5 [nucleoplasm]
(Drosophila melanogaster)
pds5 [nucleoplasm]
(Schizosaccharomyces pombe)
pds5a [nucleoplasm]
(Danio rerio)
pds5a [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001093869.1
,
NP_001093870.1
,
XP_011511974.1
,
XP_016863417.1
OpenTargets
ENSG00000121892
HPA
ENSG00000121892-PDS5A
GeneCards
Q29RF7
Ensembl
ENST00000303538
,
ENSP00000303427
,
ENSP00000426749
,
ENST00000503396
,
ENSG00000121892
PRO
Q29RF7
Pharos - Targets
Q29RF7
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60216 RAD21
14
monoSUMO1-K-RAD21 [nucleoplasm]
(R-HSA-3108183)
p-S454-RAD21 [cytosol]
(R-HSA-2500310)
p-S454-RAD21 [chromosome]
(R-HSA-2485164)
RAD21 [cytosol]
(R-HSA-2484795)
p-S454-RAD21(451-631) [cytosol]
(R-HSA-2500309)
RAD21(173-450) [cytosol]
(R-HSA-2500308)
RAD21(1-172) [cytosol]
(R-HSA-2484901)
RAD21(173-450) [chromosome, centromeric region]
(R-HSA-2500296)
p-S454-RAD21(451-631) [chromosome, centromeric region]
(R-HSA-2467790)
RAD21(1-172) [chromosome, centromeric region]
(R-HSA-2467793)
p-S454-RAD21 [chromosome, centromeric region]
(R-HSA-2485163)
RAD21 [nucleoplasm]
(R-HSA-163042)
RAD21 [chromosome, centromeric region]
(R-HSA-2466012)
RAD21 [chromosome]
(R-HSA-1638775)
0.813
5
UniProt:Q7Z5K2 WAPL
4
WAPAL [cytosol]
(R-HSA-2484802)
WAPAL [chromosome]
(R-HSA-2577090)
WAPAL [chromosome, centromeric region]
(R-HSA-2577088)
WAPAL [nucleoplasm]
(R-HSA-2466355)
0.813
9
UniProt:Q96FF9 CDCA5
6
p-S21,S75,T159-CDCA5 [chromosome]
(R-HSA-2468266)
p-S21,S75,T159-CDCA5 [cytosol]
(R-HSA-2484804)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region]
(R-HSA-2468269)
CDCA5 [chromosome]
(R-HSA-2468149)
CDCA5 [chromosome, centromeric region]
(R-HSA-2468260)
CDCA5 [nucleoplasm]
(R-HSA-2466357)
0.642
4
UniProt:Q61550 Rad21
15
Rad21 [nucleoplasm]
(R-MMU-3108183)
Double-strand-break repair protein rad21 homolog [nucleoplasm]
(R-MMU-912350)
phospho-Rad21 [cytosol]
(R-MMU-2500310)
phospho-Rad21 [chromosome]
(R-MMU-2485164)
Rad21 [cytosol]
(R-MMU-2484795)
phospho-Rad21 [cytosol]
(R-MMU-2500309)
Rad21 [cytosol]
(R-MMU-2500308)
Rad21 [cytosol]
(R-MMU-2484901)
Rad21 [chromosome, centromeric region]
(R-MMU-2500296)
phospho-Rad21 [chromosome, centromeric region]
(R-MMU-2467790)
Rad21 [chromosome, centromeric region]
(R-MMU-2467793)
phospho-Rad21 [chromosome, centromeric region]
(R-MMU-2485163)
Rad21 [chromosome]
(R-MMU-1638775)
Rad21 [chromosome, centromeric region]
(R-MMU-2466012)
Rad21 [nucleoplasm]
(R-MMU-163042)
0.564
2
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
2
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