Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
COL2A1(182-975) [extracellular region]
Stable Identifier
R-HSA-2468063
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Collagen alpha-1(II) chain N-tem fragment
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
Collagen type II degradation by MMP14 (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
Collagen type II degradation by MMP15 (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)
Cleaved collagen type XI fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type XI [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
Cleaved collagen fibrils [extracellular region] (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
Cleaved collagen type XI fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type XI [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP19 (Homo sapiens)
Cleaved collagen fibrils [extracellular region] (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
Cleaved collagen type XI fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type XI [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
COL2A1(182-975) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02458 COL2A1
Gene Names
COL2A1
Chain
signal peptide:1-25, propeptide:26-181, chain:182-1241, chain:1242-1487
Reference Genes
BioGPS Gene:1280 COL2A1
COSMIC (genes):COL2A1 COL2A1
CTD Gene:1280 COL2A1
dbSNP Gene:1280 COL2A1
ENSEMBL:ENSG00000139219 COL2A1
HGNC:2200 COL2A1
KEGG:hsa:1280 COL2A1
Monarch:1280 COL2A1
NCBI Gene:1280 COL2A1
OMIM:120140 COL2A1
UCSC:P02458 COL2A1
Reference Transcript
RefSeq:NM_001844.4 COL2A1
RefSeq:NM_033150.3 COL2A1
Participates
as a member of
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
Other forms of this molecule
GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
GalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-3Hyp-COL2A1(26-1487) [extracellular region]
COL2A1(26-1487) [extracellular region]
3x4Hyp-5Hyl-COL2A1(26-1487) [extracellular region]
GlcGalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-COL2A1(26-1487) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(26-1487) [extracellular region]
5Hyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-GalHyl-COL2A1(26-1487) [extracellular region]
5Hyl-COL2A1(182-1487) [extracellular region]
GalHyl-COL2A1(182-1487) [extracellular region]
COL2A1(182-1487) [extracellular region]
GlcGalHyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-3Hyp-COL2A1(182-1241) [extracellular region]
3x4Hyp-5Hyl-COL2A1(182-1241) [extracellular region]
GlcGalHyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(182-1241) [extracellular region]
5Hyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-COL2A1(182-1241) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]
GalHyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-GalHyl-COL2A1(182-1241) [extracellular region]
COL2A1(182-1241) [extracellular region]
5Hyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-5Hyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(182-975) [extracellular region]
COL2A1(976-1241) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-COL2A1(976-1241) [extracellular region]
GlcGalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-5Hyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-3Hyp-COL2A1(976-1241) [extracellular region]
3x4Hyp-GalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(182-975) [extracellular region]
3x4Hyp-GalHyl-COL2A1(976-1241) [extracellular region]
GlcGalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-COL2A1(182-975) [extracellular region]
5Hyl-COL2A1(182-975) [extracellular region]
GalHyl-COL2A1(182-975) [extracellular region]
GalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-5Hyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-GalHyl-COL2A1(182-1487) [extracellular region]
Inferred To
COL2A1 [extracellular region]
(Bos taurus)
COL2A1 [extracellular region]
(Canis familiaris)
COL2A1 [extracellular region]
(Sus scrofa)
Col2a1 [extracellular region]
(Mus musculus)
Col2a1 [extracellular region]
(Rattus norvegicus)
col2a1a [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001835.3
,
NP_149162.2
OpenTargets
ENSG00000139219
ENSEMBL
ENSP00000369889
,
ENST00000380518
,
ENST00000337299
,
ENSG00000139219
,
ENSP00000338213
GeneCards
COL2A1
HPA
ENSG00000139219-COL2A1
PRO
P02458
Pharos - Targets
P02458
Orphanet
COL2A1
PDB
6NIX
,
5OCX
,
6BIN
,
2SEB
,
5OCY
,
7NZE
,
5NIR
,
2FSE
,
6HG7
,
1U5M
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
