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5Hyl-COL2A1(976-1241) [extracellular region]
Stable Identifier
R-HSA-2468069
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
5-hydroxylysyl collagen alpha-1(II) chain C-term fragment
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
Collagen type II degradation by MMP14 (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
Collagen type II degradation by MMP15 (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)
Cleaved collagen type XI fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type XI [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
Cleaved collagen fibrils [extracellular region] (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
Cleaved collagen type XI fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type XI [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP19 (Homo sapiens)
Cleaved collagen fibrils [extracellular region] (Homo sapiens)
Cleaved collagen type II fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type II [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
Cleaved collagen type XI fibril [extracellular region] (Homo sapiens)
Cleaved tropocollagen type XI [extracellular region] (Homo sapiens)
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
5Hyl-COL2A1(976-1241) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02458 COL2A1
Gene Names
COL2A1
Chain
signal peptide:1-25, propeptide:26-181, chain:182-1241, chain:1242-1487
Reference Genes
BioGPS Gene:1280 COL2A1
COSMIC (genes):COL2A1 COL2A1
CTD Gene:1280 COL2A1
dbSNP Gene:1280 COL2A1
ENSEMBL:ENSG00000139219 COL2A1
HGNC:2200 COL2A1
KEGG:hsa:1280 COL2A1
Monarch:1280 COL2A1
NCBI Gene:1280 COL2A1
OMIM:120140 COL2A1
UCSC:P02458 COL2A1
Reference Transcript
RefSeq:NM_033150.2 COL2A1
RefSeq:NM_001844.4 COL2A1
Participates
as a member of
Cleaved collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
Other forms of this molecule
GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]
GalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-3Hyp-COL2A1(26-1487) [extracellular region]
COL2A1(26-1487) [extracellular region]
3x4Hyp-5Hyl-COL2A1(26-1487) [extracellular region]
GlcGalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-COL2A1(26-1487) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(26-1487) [extracellular region]
5Hyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-GalHyl-COL2A1(26-1487) [extracellular region]
5Hyl-COL2A1(182-1487) [extracellular region]
GalHyl-COL2A1(182-1487) [extracellular region]
COL2A1(182-1487) [extracellular region]
GlcGalHyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-3Hyp-COL2A1(182-1241) [extracellular region]
3x4Hyp-5Hyl-COL2A1(182-1241) [extracellular region]
GlcGalHyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(182-1241) [extracellular region]
5Hyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-COL2A1(182-1241) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]
GalHyl-COL2A1(182-1241) [extracellular region]
3x4Hyp-GalHyl-COL2A1(182-1241) [extracellular region]
COL2A1(182-1241) [extracellular region]
3x4Hyp-5Hyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(182-975) [extracellular region]
COL2A1(976-1241) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-COL2A1(976-1241) [extracellular region]
GlcGalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-5Hyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-3Hyp-COL2A1(976-1241) [extracellular region]
3x4Hyp-GalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL2A1(182-975) [extracellular region]
3x4Hyp-GalHyl-COL2A1(976-1241) [extracellular region]
GlcGalHyl-COL2A1(182-975) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(976-1241) [extracellular region]
COL2A1(182-975) [extracellular region]
3x4Hyp-COL2A1(182-975) [extracellular region]
5Hyl-COL2A1(182-975) [extracellular region]
GalHyl-COL2A1(182-975) [extracellular region]
GalHyl-COL2A1(976-1241) [extracellular region]
3x4Hyp-5Hyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-GlcGalHyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1487) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) [extracellular region]
3x4Hyp-GalHyl-COL2A1(182-1487) [extracellular region]
Inferred To
COL2A1 [extracellular region]
(Canis familiaris)
COL2A1 [extracellular region]
(Sus scrofa)
5Hyl-COL2A1(976-1241) [extracellular region]
(Bos taurus)
5Hyl-COL2A1(976-1241) [extracellular region]
(Gallus gallus)
5Hyl-COL2A1(976-1241) [extracellular region]
(Mus musculus)
5Hyl-COL2A1(976-1241) [extracellular region]
(Rattus norvegicus)
5Hyl-COL2A1(976-1241) [extracellular region]
(Xenopus tropicalis)
col2a1a [extracellular region]
(Danio rerio)
cle-1 [extracellular region]
(Caenorhabditis elegans)
Modified Residues
Name
(2S,5R)-5-hydroxylysine at unknown position
PsiMod Name
(2S,5R)-5-hydroxylysine
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.
Cross References
OpenTargets
ENSG00000139219
ENSEMBL
ENSP00000369889
,
ENSP00000338213
,
ENST00000380518
,
ENST00000337299
,
ENSG00000139219
GeneCards
COL2A1
HPA
ENSG00000139219-COL2A1
PRO
P02458
Pharos - Targets
P02458
Orphanet
COL2A1
PDB
6HG7
,
5OCY
,
2FSE
,
7NZE
,
5NIR
,
5OCX
,
6BIN
,
6NIX
,
1U5M
,
2SEB
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