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PDS5B [chromosome, centromeric region]
Stable Identifier
R-HSA-2468263
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
chromosome, centromeric region
Synonyms
Sister chromatid cohesion protein PDS5 homolog B, APRIN, AS3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
S Phase (Homo sapiens)
Establishment of Sister Chromatid Cohesion (Homo sapiens)
CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
PDS5 [chromosome, centromeric region] (Homo sapiens)
PDS5B [chromosome, centromeric region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NTI5 PDS5B
Gene Names
PDS5B, APRIN, AS3, KIAA0979
Chain
chain:1-1447
Reference Genes
COSMIC (genes):PDS5B PDS5B
dbSNP Gene:23047 PDS5B
ENSEMBL:ENSG00000083642 PDS5B
Participates
as a member of
PDS5 [chromosome, centromeric region] (Homo sapiens)
Other forms of this molecule
PDS5B [cytosol]
PDS5B [chromosome]
PDS5B [nucleoplasm]
Inferred To
evl-14 [chromosome, centromeric region]
(Caenorhabditis elegans)
PDS5B [chromosome, centromeric region]
(Bos taurus)
PDS5B [chromosome, centromeric region]
(Canis familiaris)
PDS5B [chromosome, centromeric region]
(Gallus gallus)
PDS5B [chromosome, centromeric region]
(Sus scrofa)
pds5 [chromosome, centromeric region]
(Dictyostelium discoideum)
pds5 [chromosome, centromeric region]
(Drosophila melanogaster)
pds5 [chromosome, centromeric region]
(Schizosaccharomyces pombe)
PDS5 [chromosome, centromeric region]
(Saccharomyces cerevisiae)
pds5b [chromosome, centromeric region]
(Xenopus tropicalis)
Pds5b [chromosome, centromeric region]
(Mus musculus)
Pds5b [chromosome, centromeric region]
(Rattus norvegicus)
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60216 RAD21
14
RAD21 [nucleoplasm]
(R-HSA-163042)
RAD21 [chromosome, centromeric region]
(R-HSA-2466012)
RAD21 [chromosome]
(R-HSA-1638775)
p-S454-RAD21 [chromosome, centromeric region]
(R-HSA-2485163)
p-S454-RAD21 [cytosol]
(R-HSA-2500310)
p-S454-RAD21 [chromosome]
(R-HSA-2485164)
RAD21(1-172) [chromosome, centromeric region]
(R-HSA-2467793)
p-S454-RAD21(451-631) [chromosome, centromeric region]
(R-HSA-2467790)
RAD21(173-450) [chromosome, centromeric region]
(R-HSA-2500296)
RAD21(1-172) [cytosol]
(R-HSA-2484901)
RAD21(173-450) [cytosol]
(R-HSA-2500308)
p-S454-RAD21(451-631) [cytosol]
(R-HSA-2500309)
RAD21 [cytosol]
(R-HSA-2484795)
monoSUMO1-K-RAD21 [nucleoplasm]
(R-HSA-3108183)
0.813
5
UniProt:Q7Z5K2 WAPL
4
WAPAL [cytosol]
(R-HSA-2484802)
WAPAL [chromosome]
(R-HSA-2577090)
WAPAL [chromosome, centromeric region]
(R-HSA-2577088)
WAPAL [nucleoplasm]
(R-HSA-2466355)
0.734
9
UniProt:P51587 BRCA2
20
BRCA2 D2983Ffs*34 [cytosol]
(R-HSA-9709538)
BRCA2 K2555* [cytosol]
(R-HSA-9711337)
BRCA2 N2553Tfs*95 [cytosol]
(R-HSA-9712872)
BRCA2 T2685Hfs*9 [cytosol]
(R-HSA-9712879)
BRCA2 K2674Rfs*2 [cytosol]
(R-HSA-9712610)
BRCA2 S3231* [cytosol]
(R-HSA-9711458)
BRCA2 I2675Dfs*6 [cytosol]
(R-HSA-9712869)
BRCA2 R2625* [cytosol]
(R-HSA-9711482)
BRCA2 E3071* [cytosol]
(R-HSA-9711354)
BRCA2 V2716Wfs*17 [cytosol]
(R-HSA-9712761)
BRCA2 W2586* [cytosol]
(R-HSA-9711487)
BRCA2 P2767Lfs*10 [cytosol]
(R-HSA-9712509)
BRCA2 K3032* [cytosol]
(R-HSA-9711485)
BRCA2 S2835* [cytosol]
(R-HSA-9711345)
BRCA2 Y3006* [cytosol]
(R-HSA-9711222)
BRCA2 L2926* [cytosol]
(R-HSA-9711348)
BRCA2 R3128* [cytosol]
(R-HSA-9711177)
BRCA2 E2599* [cytosol]
(R-HSA-9711304)
BRCA2 E2571* [cytosol]
(R-HSA-9711560)
BRCA2 Y2977* [cytosol]
(R-HSA-9711182)
0.641
26
UniProt:Q9CPY3
6
phospho-Cdca5 [cytosol]
(R-MMU-2484804)
phospho-Cdca5 [chromosome, centromeric region]
(R-MMU-2468269)
phospho-Cdca5 [chromosome]
(R-MMU-2468266)
Cdca5 [chromosome]
(R-MMU-2468149)
Cdca5 [chromosome, centromeric region]
(R-MMU-2468260)
Cdca5 [nucleoplasm]
(R-MMU-2466357)
0.564
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.564
2
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