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p-S21,S75,T159-CDCA5 [chromosome, centromeric region]
Stable Identifier
R-HSA-2468269
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
chromosome, centromeric region
Synonyms
p-S21,S75,T159-Sororin
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96FF9 CDCA5
Gene Names
CDCA5
Chain
chain:1-252
Reference Genes
BioGPS Gene:113130 CDCA5
COSMIC (genes):CDCA5 CDCA5
CTD Gene:113130 CDCA5
dbSNP Gene:113130 CDCA5
ENSEMBL:ENSG00000146670 CDCA5
ENSEMBL_homo_sapiens_GENE:ENSG00000146670.10 CDCA5
HGNC:14626 CDCA5
KEGG Gene (Homo sapiens):113130 CDCA5
Monarch:113130 CDCA5
NCBI Gene:113130 CDCA5
OMIM:609374 CDCA5
UCSC:Q96FF9 CDCA5
Reference Transcript
RefSeq:NM_080668.3 CDCA5
Other Identifiers
113130
11718182_at
11718183_at
224753_PM_at
224753_at
3377426
3377427
3377429
3377430
3377431
3377432
3377433
3377434
3377435
3377437
3377438
44037_at
7949364
A_23_P104651
GE478996
GO:0000278
GO:0000775
GO:0000785
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006281
GO:0006302
GO:0007049
GO:0007059
GO:0007064
GO:0007076
GO:0007080
GO:0031536
GO:0043226
GO:0044877
GO:0051301
GO:0140014
HMNXSV003023496
HMNXSV003056557
Hs.23044.2.A1_3p_at
ILMN_1683450
PH_hs_0020362
TC11001924.hg
Participates
as a component of
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Other forms of this molecule
p-S21,S75,T159-CDCA5 [chromosome]
p-S21,S75,T159-CDCA5 [cytosol]
CDCA5 [chromosome]
CDCA5 [chromosome, centromeric region]
CDCA5 [nucleoplasm]
Inferred To
phospho-CDCA5 [chromosome, centromeric region]
(Bos taurus)
phospho-CDCA5 [chromosome, centromeric region]
(Canis familiaris)
phospho-CDCA5 [chromosome, centromeric region]
(Sus scrofa)
Ghost homologue of p-S21,S75,T159-CDCA5 [chromosome, centromeric region]
(Gallus gallus)
phospho-cdca5 [chromosome, centromeric region]
(Xenopus tropicalis)
phospho-Cdca5 [chromosome, centromeric region]
(Mus musculus)
phospho-Cdca5 [chromosome, centromeric region]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 159
Coordinate
159
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 21
Coordinate
21
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 75
Coordinate
75
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_542399.1
OpenTargets
ENSG00000146670
GeneCards
Q96FF9
HPA
ENSG00000146670-CDCA5
Ensembl
ENSP00000275517
,
ENST00000275517
,
ENSG00000146670
PRO
Q96FF9
Pharos - Targets
Q96FF9
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14683 SMC1A
4
SMC1A [cytosol]
(R-HSA-2484798)
SMC1A [chromosome]
(R-HSA-1638774)
SMC1A [chromosome, centromeric region]
(R-HSA-2466015)
SMC1A [nucleoplasm]
(R-HSA-64561)
0.832
8
UniProt:Q9UQE7 SMC3
6
SMC3 [cytosol]
(R-HSA-2545223)
2xAcK-SMC3 [cytosol]
(R-HSA-2484792)
2xAcK-SMC3 [chromosome]
(R-HSA-2468146)
2xAcK-SMC3 [chromosome, centromeric region]
(R-HSA-2468148)
2xAcK-SMC3 [nucleoplasm]
(R-HSA-2468050)
SMC3 [nucleoplasm]
(R-HSA-163009)
0.744
6
UniProt:P41227 NAA10
0.666
7
UniProt:O60216 RAD21
14
monoSUMO1-K-RAD21 [nucleoplasm]
(R-HSA-3108183)
p-S454-RAD21 [cytosol]
(R-HSA-2500310)
p-S454-RAD21 [chromosome]
(R-HSA-2485164)
RAD21 [cytosol]
(R-HSA-2484795)
p-S454-RAD21(451-631) [cytosol]
(R-HSA-2500309)
RAD21(173-450) [cytosol]
(R-HSA-2500308)
RAD21(1-172) [cytosol]
(R-HSA-2484901)
RAD21(173-450) [chromosome, centromeric region]
(R-HSA-2500296)
p-S454-RAD21(451-631) [chromosome, centromeric region]
(R-HSA-2467790)
RAD21(1-172) [chromosome, centromeric region]
(R-HSA-2467793)
p-S454-RAD21 [chromosome, centromeric region]
(R-HSA-2485163)
RAD21 [chromosome]
(R-HSA-1638775)
RAD21 [nucleoplasm]
(R-HSA-163042)
RAD21 [chromosome, centromeric region]
(R-HSA-2466012)
0.643
4
UniProt:Q8N3U4 STAG2
8
monoSUMO1-K-STAG2 [nucleoplasm]
(R-HSA-3108187)
p-STAG2 [chromosome, centromeric region]
(R-HSA-2466013)
p-STAG2 [cytosol]
(R-HSA-2484806)
p-STAG2 [chromosome]
(R-HSA-1638793)
STAG2 [cytosol]
(R-HSA-2484897)
STAG2 [chromosome]
(R-HSA-1638777)
STAG2 [chromosome, centromeric region]
(R-HSA-2466018)
STAG2 [nucleoplasm]
(R-HSA-163046)
0.643
5
UniProt:Q29RF7 PDS5A
4
PDS5A [cytosol]
(R-HSA-2484799)
PDS5A [chromosome]
(R-HSA-2466360)
PDS5A [chromosome, centromeric region]
(R-HSA-2468259)
PDS5A [nucleoplasm]
(R-HSA-2468043)
0.642
4
UniProt:Q9CW03 Smc3
6
SMC3 [cytosol]
(R-MMU-2545223)
2xAcK-SMC3 [cytosol]
(R-MMU-2484792)
2xAcK-SMC3 [chromosome]
(R-MMU-2468146)
2xAcK-SMC3 [chromosome, centromeric region]
(R-MMU-2468148)
2xAcK-SMC3 [nucleoplasm]
(R-MMU-2468050)
Structural maintenance of chromosomes protein 3 [nucleoplasm]
(R-MMU-912387)
0.564
3
UniProt:Q5FBB7 SGO1
1
SGOL1 [cytosol]
(R-HSA-376227)
0.558
4
UniProt:Q9BSU3 NAA11
0.556
3
UniProt:Q8N3U4-2 STAG2
0.527
2
UniProt:Q8WVM7 STAG1
4
STAG1 [cytosol]
(R-HSA-2484793)
STAG1 [chromosome]
(R-HSA-1638773)
STAG1 [nucleoplasm]
(R-HSA-163016)
STAG1 [chromosome, centromeric region]
(R-HSA-2466017)
0.527
2
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