ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin

Stable Identifier
R-HSA-2470508
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin
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As inferred from mouse, upon binding Activin AB (INHBA:INHBB) or Activin B (INHBB:INHBB), the type II component of the activin receptor (ACVR2A or ACVR2B) phosphorylates the type I component ACVR1C (ALK7) at multiple serine and threonine residues within the GS domain.

Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane]

Physical Entity
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Acvr2a phosphorylates Acvr1c in response to Activin (Mus musculus)
Authored
May, B  (2011-01-23)
Reviewed
Chen, YG  (2012-11-14)
Created
May, B  (2012-09-19)
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