Reactome | Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2

Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2

Stable Identifier

R-HSA-2470935

Type

Reaction [transition]

Species

Homo sapiens

Compartment

chromosome, nucleoplasm

ReviewStatus

5/5

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Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2

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Cohesin, in complex with WAPAL and PDS5 (PDS5A or PDS5B) binds decondensed chromatin in telophase (Kueng et al. 2006). This binding is facilitated by the NIPBL:MAU2 complex, also known as the 'cohesin loading complex'. NIPBL:MAU2 complex is associated with chromatin from telophase until prophase (Watrin et al. 2006) but seems to form a transient rather than stable complex with cohesin.

Literature References

PubMed ID	Title	Journal	Year
17113138	Wapl controls the dynamic association of cohesin with chromatin Peters, BH, Hegemann, B, Peters, JM, Mechtler, K, Schleiffer, A, Kueng, S, Lipp, JJ	Cell	2006
16682347	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression Nasmyth, K, Peters, JM, Tanaka, K, Schleiffer, A, Watrin, E, Eisenhaber, F	Curr. Biol.	2006