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Go!
RAD21 [cytosol]
Stable Identifier
R-HSA-2484795
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Deacetylation of cleaved cohesin (Homo sapiens)
Cohesin Complex [cytosol] (Homo sapiens)
RAD21 [cytosol] (Homo sapiens)
RAD21 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60216 RAD21
Gene Names
RAD21, HR21, KIAA0078, NXP1, SCC1
Chain
chain:1-631, chain:280-631
Reference Genes
BioGPS Gene:5885 RAD21
COSMIC (genes):RAD21 RAD21
CTD Gene:5885 RAD21
dbSNP Gene:5885 RAD21
ENSEMBL:ENSG00000164754 RAD21
HGNC:9811 RAD21
KEGG:hsa:5885 RAD21
Monarch:5885 RAD21
NCBI Gene:5885 RAD21
OMIM:606462 RAD21
UCSC:O60216 RAD21
Reference Transcript
RefSeq:NM_006265.2 RAD21
Other Identifiers
11716436_s_at
11716437_a_at
11716438_at
11754303_s_at
17080408
200607_PM_s_at
200607_s_at
200608_PM_s_at
200608_s_at
3149847
3149848
3149849
3149850
3149851
3149852
3149853
3149854
3149855
3149856
3149857
3149858
3149859
3149860
3149861
3149862
3149863
3149864
3149865
3149866
3149868
3149869
3149871
3149872
3149873
3149874
3149880
3149881
3149882
3149883
38114_at
3984533
3984537
5885
8152477
D38551_at
GE57195
GO:0000228
GO:0000775
GO:0000785
GO:0000794
GO:0000922
GO:0001666
GO:0003677
GO:0003682
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0006355
GO:0006357
GO:0006915
GO:0007059
GO:0007062
GO:0007131
GO:0008278
GO:0010628
GO:0010629
GO:0010972
GO:0012501
GO:0016020
GO:0016363
GO:0030496
GO:0030892
GO:0030893
GO:0032691
GO:0032720
GO:0032733
GO:0034087
GO:0034089
GO:0034351
GO:0043226
GO:0043524
GO:0045841
GO:0045876
GO:0051301
GO:0071168
GO:0106222
GO:0140297
GO:0140588
GO:1990414
HMNXSV003020959
HMNXSV003027934
Hs.81848.0.S1_3p_a_at
ILMN_1748578
PH_hs_0004675
TC08001546.hg
g5453993_3p_a_at
Participates
as a component of
Cohesin Complex [cytosol] (Homo sapiens)
as an input of
Deacetylation of cleaved cohesin (Homo sapiens)
Other forms of this molecule
RAD21 [nucleoplasm]
RAD21 [chromosome, centromeric region]
RAD21 [chromosome]
p-S454-RAD21 [chromosome, centromeric region]
p-S454-RAD21 [cytosol]
p-S454-RAD21 [chromosome]
RAD21(1-172) [chromosome, centromeric region]
p-S454-RAD21(451-631) [chromosome, centromeric region]
RAD21(173-450) [chromosome, centromeric region]
RAD21(1-172) [cytosol]
RAD21(173-450) [cytosol]
p-S454-RAD21(451-631) [cytosol]
monoSUMO1-K-RAD21 [nucleoplasm]
Inferred To
coh-1 [cytosol]
(Caenorhabditis elegans)
Homologues of RAD21 [cytosol]
(Caenorhabditis elegans)
Homologues of RAD21 [cytosol]
(Saccharomyces cerevisiae)
Homologues of RAD21 [cytosol]
(Schizosaccharomyces pombe)
RAD21 [cytosol]
(Bos taurus)
RAD21 [cytosol]
(Canis familiaris)
RAD21 [cytosol]
(Dictyostelium discoideum)
RAD21 [cytosol]
(Gallus gallus)
RAD21 [cytosol]
(Sus scrofa)
Rad21 [cytosol]
(Mus musculus)
Rad21 [cytosol]
(Rattus norvegicus)
vtd [cytosol]
(Drosophila melanogaster)
rec-8 [cytosol]
(Caenorhabditis elegans)
rec8 [cytosol]
(Schizosaccharomyces pombe)
rad21b [cytosol]
(Danio rerio)
REC8 [cytosol]
(Saccharomyces cerevisiae)
scc-1 [cytosol]
(Caenorhabditis elegans)
MCD1 [cytosol]
(Saccharomyces cerevisiae)
rad21 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_006256.1
OpenTargets
ENSG00000164754
ENSEMBL
ENST00000687358
,
ENSP00000429342
,
ENST00000517485
,
ENSP00000428158
,
ENSP00000427923
,
ENSP00000430524
,
ENSP00000509687
,
ENST00000297338
,
ENST00000520992
,
ENST00000522699
,
ENST00000519837
,
ENSP00000297338
,
ENSP00000430273
,
ENST00000517749
HPA
ENSG00000164754-RAD21
PRO
O60216
Pharos - Targets
O60216
GlyGen
O60216
Orphanet
RAD21
PDB
6RRK
,
6QNX
,
4PJW
,
4PK7
,
6WGE
,
7ZJS
,
7W1M
,
6WG3
,
6RRC
,
4PJU
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N3U4 STAG2
8
monoSUMO1-K-STAG2 [nucleoplasm]
(R-HSA-3108187)
STAG2 [cytosol]
(R-HSA-2484897)
p-STAG2 [chromosome]
(R-HSA-1638793)
p-STAG2 [cytosol]
(R-HSA-2484806)
p-STAG2 [chromosome, centromeric region]
(R-HSA-2466013)
STAG2 [chromosome]
(R-HSA-1638777)
STAG2 [chromosome, centromeric region]
(R-HSA-2466018)
STAG2 [nucleoplasm]
(R-HSA-163046)
0.966
22
UniProt:Q9UQE7 SMC3
6
SMC3 [cytosol]
(R-HSA-2545223)
2xAcK-SMC3 [cytosol]
(R-HSA-2484792)
2xAcK-SMC3 [chromosome]
(R-HSA-2468146)
2xAcK-SMC3 [chromosome, centromeric region]
(R-HSA-2468148)
2xAcK-SMC3 [nucleoplasm]
(R-HSA-2468050)
SMC3 [nucleoplasm]
(R-HSA-163009)
0.956
18
UniProt:Q14683 SMC1A
4
SMC1A [cytosol]
(R-HSA-2484798)
SMC1A [chromosome]
(R-HSA-1638774)
SMC1A [chromosome, centromeric region]
(R-HSA-2466015)
SMC1A [nucleoplasm]
(R-HSA-64561)
0.926
18
UniProt:Q8WVM7 STAG1
4
STAG1 [nucleoplasm]
(R-HSA-163016)
STAG1 [chromosome, centromeric region]
(R-HSA-2466017)
STAG1 [chromosome]
(R-HSA-1638773)
STAG1 [cytosol]
(R-HSA-2484793)
0.918
12
UniProt:Q7Z5K2 WAPL
4
WAPAL [cytosol]
(R-HSA-2484802)
WAPAL [chromosome]
(R-HSA-2577090)
WAPAL [chromosome, centromeric region]
(R-HSA-2577088)
WAPAL [nucleoplasm]
(R-HSA-2466355)
0.905
18
UniProt:Q29RF7 PDS5A
4
PDS5A [cytosol]
(R-HSA-2484799)
PDS5A [chromosome]
(R-HSA-2466360)
PDS5A [chromosome, centromeric region]
(R-HSA-2468259)
PDS5A [nucleoplasm]
(R-HSA-2468043)
0.857
6
UniProt:Q9NTI5 PDS5B
4
PDS5B [cytosol]
(R-HSA-2484800)
PDS5B [chromosome]
(R-HSA-2466361)
PDS5B [chromosome, centromeric region]
(R-HSA-2468263)
PDS5B [nucleoplasm]
(R-HSA-2468051)
0.813
5
UniProt:Q5FBB7 SGO1
1
SGOL1 [cytosol]
(R-HSA-376227)
0.737
6
UniProt:Q9NP77 SSU72
1
SSU72 [nucleoplasm]
(R-HSA-6814915)
0.674
9
UniProt:Q9CPY3
6
phospho-Cdca5 [cytosol]
(R-MMU-2484804)
phospho-Cdca5 [chromosome, centromeric region]
(R-MMU-2468269)
phospho-Cdca5 [chromosome]
(R-MMU-2468266)
Cdca5 [chromosome]
(R-MMU-2468149)
Cdca5 [chromosome, centromeric region]
(R-MMU-2468260)
Cdca5 [nucleoplasm]
(R-MMU-2466357)
0.669
3
UniProt:Q13643 FHL3
0.666
4
UniProt:Q96FF9 CDCA5
6
p-S21,S75,T159-CDCA5 [cytosol]
(R-HSA-2484804)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region]
(R-HSA-2468269)
p-S21,S75,T159-CDCA5 [chromosome]
(R-HSA-2468266)
CDCA5 [chromosome]
(R-HSA-2468149)
CDCA5 [chromosome, centromeric region]
(R-HSA-2468260)
CDCA5 [nucleoplasm]
(R-HSA-2466357)
0.643
4
UniProt:Q9CW03 Smc3
6
SMC3 [cytosol]
(R-MMU-2545223)
2xAcK-SMC3 [cytosol]
(R-MMU-2484792)
2xAcK-SMC3 [chromosome]
(R-MMU-2468146)
2xAcK-SMC3 [chromosome, centromeric region]
(R-MMU-2468148)
2xAcK-SMC3 [nucleoplasm]
(R-MMU-2468050)
Structural maintenance of chromosomes protein 3 [nucleoplasm]
(R-MMU-912387)
0.597
5
UniProt:Q92995 USP13
2
USP13 [nucleoplasm]
(R-HSA-6781924)
USP13 [cytosol]
(R-HSA-6781893)
0.527
2
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.527
2
UniProt:Q96K76 USP47
1
USP47 [nucleoplasm]
(R-HSA-5696961)
0.527
2
UniProt:Q9BSQ5 CCM2
0.527
2
UniProt:P35998 PSMC2
5
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
0.527
2
UniProt:Q8N3U4-2 STAG2
0.527
2
UniProt:Q9NTI5-2 PDS5B
0.527
2
UniProt:P13497 BMP1
1
BMP1 [extracellular region]
(R-HSA-2002393)
0.527
2
UniProt:Q9HCH3 CPNE5
0.527
2
UniProt:A9IYQ1 A9IYQ1
0.527
2
UniProt:Q8NFQ8 TOIP2
0.527
2
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