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ESPL1(1507-1535) [cytosol]
Stable Identifier
R-HSA-2500272
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ESPL1 middle fragment, Separin middle fragment, Separase middle fragment
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Autocleavage of ESPL1 (Separase) (Homo sapiens)
ESPL1 Autocleaved [cytosol] (Homo sapiens)
ESPL1(1507-1535) [cytosol] (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
ESPL1 Autocleaved [cytosol] (Homo sapiens)
ESPL1(1507-1535) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14674 ESPL1
Gene Names
ESPL1, ESP1, KIAA0165
Chain
chain:1-2120
Reference Genes
BioGPS Gene:9700 ESPL1
COSMIC (genes):ESPL1 ESPL1
CTD Gene:9700 ESPL1
dbSNP Gene:9700 ESPL1
ENSEMBL:ENSG00000135476 ESPL1
ENSEMBL_homo_sapiens_GENE:ENSG00000135476.12 ESPL1
HGNC:16856 ESPL1
KEGG Gene (Homo sapiens):9700 ESPL1
Monarch:9700 ESPL1
NCBI Gene:9700 ESPL1
OMIM:604143 ESPL1
UCSC:Q14674 ESPL1
Reference Transcript
RefSeq:NM_012291.4 ESPL1
RefSeq:XM_006719705.3 ESPL1
RefSeq:XM_011539024.2 ESPL1
RefSeq:XM_017020253.1 ESPL1
Other Identifiers
11723909_at
11748054_a_at
16751709
204817_PM_at
204817_at
3415858
3415860
3415862
3415863
3415864
3415865
3415866
3415867
3415868
3415869
3415870
3415871
3415872
3415873
3415877
3415878
3415880
3415881
3415882
3415883
3415884
3415885
3415886
3415887
3415889
3415890
3415891
3415892
3415894
3415895
3415896
3415897
3415899
3415900
3415902
3415904
3415905
3415906
3415907
3415908
3415909
3415910
3415911
3415912
3415913
3415914
38158_PM_at
38158_at
7955736
9700
A_23_P32707
A_32_P119007
D79987_at
GE79012
GO:0000070
GO:0000212
GO:0000278
GO:0000280
GO:0000281
GO:0000910
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006508
GO:0006915
GO:0007010
GO:0007059
GO:0007127
GO:0008233
GO:0008234
GO:0012501
GO:0016787
GO:0022414
GO:0040001
GO:0043226
GO:0045143
GO:0045842
GO:0045875
GO:0051306
GO:0051307
GO:0072686
GO:0098813
GO:0140013
GO:0140014
GO:0140096
HMNXSV003041872
ILMN_1742145
PH_hs_0009230
TC12000434.hg
g6912453_3p_at
g6912453_3p_s_at
Participates
as a component of
ESPL1 Autocleaved [cytosol] (Homo sapiens)
Other forms of this molecule
ESPL1(1-1506) [cytosol]
ESPL1(1536-2120) [cytosol]
ESPL1 [cytosol]
Inferred To
ESP1 [cytosol]
(Saccharomyces cerevisiae)
cut1 [cytosol]
(Schizosaccharomyces pombe)
espl1 [cytosol]
(Xenopus tropicalis)
sep-1 [cytosol]
(Caenorhabditis elegans)
ESPL1(1507-1535) [cytosol]
(Dictyostelium discoideum)
ESPL1(1507-1535) [cytosol]
(Gallus gallus)
ESPL1(1507-1535) [cytosol]
(Plasmodium falciparum)
Espl1 [cytosol]
(Mus musculus)
Espl1 [cytosol]
(Rattus norvegicus)
ESPL1 [cytosol]
(Bos taurus)
ESPL1 [cytosol]
(Canis familiaris)
ESPL1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_006719768.1
,
XP_011537326.1
,
NP_036423.4
,
XP_016875742.1
OpenTargets
ENSG00000135476
GeneCards
Q14674
HPA
ENSG00000135476-ESPL1
Ensembl
ENST00000257934
,
ENSP00000257934
,
ENSG00000135476
PRO
Q14674
Pharos - Targets
Q14674
PDB
7NJ1
,
7NJ0
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95997 PTTG1
2
K11polyUb-PTTG1 [cytosol]
(R-HSA-3095943)
PTTG1 [cytosol]
(R-HSA-174190)
0.803
8
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.597
3
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.499
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.462
2
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