The MSR1:ligand complex (SCARA1:ligand, SR-A:ligand) is endocytosed (Matsumoto et al. 1990, Gough et al. 1998, Peiser et al. 2000, Aguilar-Gaytan and Mas-Oliva 2003, Wang and Chandawarkar 2010, Orr et al. 2011). In the cases in which the ligands are located on bacteria or yeast cells the entire cell is phagocytosed (Aguilar-Gaytan and Mas-Oliva 2003, Wang and Chandawarkar 2010). Uptake of modified LDL by macrophages via MSR1 appears to contribute to foam cell formation during atherosclerosis (Matsumoto et al. 1990).
Aguilar-Gaytan, R, Mas-Oliva, J
Gordon, S, Kodama, T, Peiser, L, Gough, PJ
Chrisler, WB, Tarasevich, BJ, Thrall, BD, Zangar, RC, Markillie, LM, Tan, R, Orr, GA, Cassens, KJ
Ikemoto, S, Kanamori, H, Takaku, F, Itakura, H, Asaoka, H, Aburatani, H, Hayakawa, I, Matsumoto, A, Suzuki, H, Naito, M
Wang, R, Chandawarkar, RY
Greaves, DR, Gough, PJ, Gordon, S
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