ITPA hydrolyses XTP to XMP

Stable Identifier
R-HSA-2509831
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
XTP + H2O => XMP + PPi
ReviewStatus
5/5
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General
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Cytosolic ITPA dimer catalyzes the reaction of XTP and water to form XMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of XTP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).
Literature References
PubMed ID Title Journal Year
20081199 NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Iyama, T, Ohno, M, Nakabeppu, Y, Sakumi, K, Abolhassani, N, Behmanesh, M, Tsuchimoto, D

Nucleic Acids Res. 2010
11278832 Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene

Gu, S, Jin, H, Ying, K, Tang, R, Liu, W, Xie, Y, Yuan, Y, Mao, Y, McLennan, AG, Lin, S, Wu, C, Wang, Z

J. Biol. Chem. 2001
Participants
Participates
Catalyst Activity

XTP diphosphatase activity of ITPA dimer [cytosol]

This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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