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LDL [endocytic vesicle lumen]
Stable Identifier
R-HSA-2512797
Type
Complex
Species
Homo sapiens
Compartment
endocytic vesicle lumen
Synonyms
low-density lipoprotein complex
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class B Receptors (Homo sapiens)
SCARB1:ligand is endocytosed (Homo sapiens)
SCARB1:Endocytosed Ligand [endocytic vesicle membrane] (Homo sapiens)
Endocytosed Ligands of SCARB1 [endocytic vesicle lumen] (Homo sapiens)
LDL [endocytic vesicle lumen] (Homo sapiens)
General
LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
Participants
components
APOB(28-4563) [endocytic vesicle lumen]
(Homo sapiens)
x 670
cholesterol [endocytic vesicle lumen]
x 1500
cholesterol esters [endocytic vesicle lumen]
x 690
PL [endocytic vesicle lumen]
x 170
TAGs [endocytic vesicle lumen]
Participates
as a member of
Endocytosed Ligands of SCARB1 [endocytic vesicle lumen] (Homo sapiens)
Inferred To
LDL [endocytic vesicle lumen]
(Bos taurus)
LDL [endocytic vesicle lumen]
(Canis familiaris)
LDL [endocytic vesicle lumen]
(Gallus gallus)
LDL [endocytic vesicle lumen]
(Mus musculus)
LDL [endocytic vesicle lumen]
(Rattus norvegicus)
LDL [endocytic vesicle lumen]
(Sus scrofa)
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