Reactome | SCARB1:ligand is endocytosed

SCARB1:ligand is endocytosed

Stable Identifier

R-HSA-2512800

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endocytic vesicle membrane, plasma membrane

ReviewStatus

5/5

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The SCARB1 (SR-BI, SR-BII):ligand complex is endocytosed (Calvo et al. 1997, Murao et al. 1997, Rhainds et al. 1999, Vishnyakova et al. 2003, Baranova et al. 2005, Eckhardt et al. 2004) but selective lipid uptake from lipoprotein particles does not require SR-BI endocytosis in mouse (Nieland et al. 2005) but is partly dependent on endocytosis in human (Zhang et al. 2007). HDL particles are resecreted after lipid unloading in the endocytic pathway (Pagler et al. 2006; Zhang et al. 2007). SR-BI colocalizes with caveolae (inferred from mouse, Babitt et al. 1997) while SR-BII, an alternatively spliced form of SCARB1, localizes to clathrin-coated pits due to a dileucine motif in the cytosolic tail (inferred from mouse, Eckhardt et al. 2006). Endocytosis of oxidized LDL by SR-BI is independent of caveolae, microtubules, and actin cytoskeleton (inferred from mouse, Sun et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17876058	Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI Shridas, P, Sun, B, Connelly, MA, Boyanovsky, BB, van der Westhuyzen, DR, Webb, NR	J. Lipid Res.	2007
16488891	SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux Strobl, W, Neuhofer, A, Hinterndorfer, C, Eckhardt, ER, Rhode, S, Schütz, GJ, Stangl, H, Volf, I, Pagler, TA, Pavelka, M, van der Westhuyzen, DR, Laggner, H	J. Biol. Chem.	2006
14726519	High density lipoprotein uptake by scavenger receptor SR-BII Sun, B, Cai, L, Eckhardt, ER, van der Westhuyzen, DR, Webb, NR	J. Biol. Chem.	2004
12651854	Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1 Baranova, IN, Remaley, AT, Patterson, AP, Csako, G, Eggerman, TL, Bocharov, AV, Chen, Z, Vishnyakova, TG	J Biol Chem	2003
15576377	Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases Baranova, IN, Thomas, F, Remaley, AT, Kimelman, ML, Kurlander, R, Patterson, AP, Csako, G, Eggerman, TL, Bocharov, AV, Chen, Z, Vishnyakova, TG	J Biol Chem	2005
17710648	The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I Truant, R, Trigatti, BL, Ahmed, AM, Igdoura, SA, Tran, TL, Zhang, Y, McFarlane, N, Boreham, DR, Lin, J	Mol. Membr. Biol.	2007
16368683	High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif Shetty, S, Cai, L, Eckhardt, ER, Szanto, A, Zhao, Z, van der Westhuyzen, DR, Webb, NR	J. Biol. Chem.	2006
9211901	Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes Terpstra, V, Green, SR, Murao, K, Kondratenko, N, Steinberg, D, Quehenberger, O	J Biol Chem	1997
10103054	Uptake and fate of class B scavenger receptor ligands in HepG2 cells Tremblay, C, Rhainds, D, Falstrault, L, Brissette, L	Eur J Biochem	1999
9148942	Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae Babitt, J, Smart, EJ, Krieger, M, Xu, S, Anderson, RG, Rigotti, A, Trigatti, B	J. Biol. Chem.	1997
15866482	Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI Kirchhausen, T, Krieger, M, Nieland, TJ, Ehrlich, M	Biochim. Biophys. Acta	2005
9409200	CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins Vega, MA, Lasunción, MA, Gómez-Coronado, D, Calvo, D	Arterioscler Thromb Vasc Biol	1997