Reactome | CK2 phosphorylates condensin I subunits

CK2 phosphorylates condensin I subunits

Stable Identifier

R-HSA-2529020

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Protein levels of condensin subunits are constant during the cell cycle. Four subunits, SMC4, NCAPD2, NCAPG and NCAPH, are phosphorylated in interphase cells (Takemoto et al. 2004) by CK2 i.e. casein kinase II (Takemoto et al. 2006). Except for the phosphorylation of NCAPH subunit on serine residue S570, CK2 phosphorylation sites in condensin I subunits have not been identified. Phosphorylation by CK2 inhibits condensin I-mediated introduction of positive supercoils into DNA and chromatin condensation. Mitotic activation of condensin I involves removal of phosphate groups added by CK2 (Takemoto et al. 2006), but the responsible phosphatase has not been identified.

Literature References

PubMed ID	Title	Journal	Year
17066080	Negative regulation of condensin I by CK2-mediated phosphorylation Kimura, K, Yanagisawa, J, Hanaoka, F, Takemoto, A, Yokoyama, S	EMBO J.	2006
14607834	Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin Kimura, K, Hanaoka, F, Takemoto, A, Yokoyama, S	J. Biol. Chem.	2004