FNTA:FNTB transfers FARN to GNGT1

Stable Identifier
Reaction [transition]
Homo sapiens
Farnesyltransferase complex farnesylates the gamma subunit of transducin
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Prenylation is the process of post-translational addition of hydrophobic groups to proteins and is thought to help anchor proteins to cellular membranes. Farnesylation is a type of prenylation, where a farnesyl group (donated from farnesyl diphosphate, FPP) is added to a cysteine residue on a protein. The enzyme mediating this transfer is farnesyltransferase (FNT). FNT is a heterodimer comprising an alpha subunit (common to another prenylating enzyme called geranylgeranyltransferase, GGT) and a unique beta subunit (Long et al. 2001, Bell et al. 2002, deSolms et al. 2003). This complex recognises the CAAX box (C is the cysteine, A is any aliphatic amino acid, and X determines which enzyme acts on the protein) at the C-terminus of the target protein, in this case, the gamma subunit of transducin (GNG1) (Omer at al. 1993).
Literature References
PubMed ID Title Journal Year
12036349 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency

Taylor, JS, Gallicchio, SN, Bhimnathwala, H, Zartman, CB, Huber, HE, Graham, SL, Gibbs, JB, Huff, JR, Buser, CA, Hartman, GD, Ellis-Hutchings, M, Abrams, M, Heimbrook, DC, Koblan, KS, Lynch, JJ, Kohl, NE, Beese, LS, Williams, TM, Fernandes, C, Bell, IM, Walsh, ES, Hamilton, KA, Beshore, DC, Rodrigues, AD, Davide, J, Lobell, RB, Culberson, JC, Homnick, CF, Kassahun, K, Bogusky, MJ, Robinson, R

J. Med. Chem. 2002
12825937 Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

Taylor, JS, Robinson, RG, Kohl, NE, Beese, LS, Tsou, NN, Graham, SL, Huber, HE, Buser, CA, Fernandes, C, Walsh, ES, Hamilton, KA, deSolms, SJ, MacTough, SC, Ellis-Hutchings, M, Shaw, AW, Lobell, RB, Ciccarone, TM

J. Med. Chem. 2003
8494894 Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Kohl, NE, Diehl, RE, Powers, S, Gibbs, JB, Kral, AM, Allen, CM, Omer, CA, Prendergast, GC

Biochemistry 1993
11687658 The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics

Beese, LS, Kral, AM, Hellinga, HW, Hancock, PJ, Long, SB

Proc. Natl. Acad. Sci. U.S.A. 2001
Catalyst Activity

protein farnesyltransferase activity of FNTA:FNTB [cytosol]

Orthologous Events
Cite Us!