Reactome | NEK7 [cytosol]

NEK7 [cytosol]

Stable Identifier

R-HSA-2530599

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase Nek7, NimA-related protein kinase 7

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8TDX7 NEK7

Gene Names

NEK7

Chain

chain:1-302

Reference Genes

BioGPS Gene:140609 NEK7

COSMIC (genes):NEK7 NEK7

CTD Gene:140609 NEK7

dbSNP Gene:140609 NEK7

ENSEMBL:ENSG00000151414 NEK7

HGNC:13386 NEK7

KEGG Gene (Homo sapiens):140609 NEK7

Monarch:140609 NEK7

NCBI Gene:140609 NEK7

OMIM:606848 NEK7

UCSC:Q8TDX7 NEK7

Reference Transcript

RefSeq:NM_133494.2 NEK7

Other Identifiers

0000770348

11717450_a_at

11717451_at

11717452_x_at

140609

16675558

212530_at

2373749

2373750

2373751

2373773

2373774

2373785

2373786

2373789

2373790

2373796

2373798

2373802

2373804

2373805

2373815

2373816

2373817

2373818

2373823

2373825

2373827

2373829

2373831

34752_at

69905_r_at

7908543

91600_at

A_14_P103773

A_14_P118223

A_23_P201619

A_23_P353574

A_33_P3318475

GE471590

GE56338

GO:0000166

GO:0000278

GO:0000922

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005815

GO:0005856

GO:0005874

GO:0006259

GO:0006464

GO:0006468

GO:0007010

GO:0007049

GO:0007346

GO:0008150

GO:0009058

GO:0016301

GO:0016310

GO:0016740

GO:0022607

GO:0032212

GO:0034641

GO:0042592

GO:0043167

GO:0043226

GO:0046872

GO:0051225

GO:0051276

GO:0051973

GO:0106310

GO:0106311

GO:1904355

HMNXSV003037969

HMNXSV003046155

Hs.24119.0.S1_3p_at

ILMN_1758548

ILMN_1869897

PH_hs_0027102

PH_hs_0040147

TC01001639.hg

Participates

as a candidate of

NEK6/NEK7 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S195-NEK7 [cytosol]

Inferred To

nek7 [cytosol] (Danio rerio)

NEK7 [cytosol] (Bos taurus)

NEK7 [cytosol] (Canis familiaris)

NEK7 [cytosol] (Gallus gallus)

NEK7 [cytosol] (Sus scrofa)

nekl-3 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_598001.1

ZINC - World Drugs

NEK7_HUMAN

Guide to Pharmacology - Targets

2122

OpenTargets

ENSG00000151414

ZINC - FDA approved

NEK7_HUMAN

ZINC - Substances

NEK7_HUMAN

ZINC target

Q8TDX7

ZINC - Biogenic

NEK7_HUMAN

PRO

Q8TDX7

GlyGen

Q8TDX7

PDB

6S73, 2WQM, 5DE2, 2WQN, 6S76, 6S75, 6NPY

ZINC - Investigational

NEK7_HUMAN

IntEnz

2.7.11.1

GeneCards

Q8TDX7

HPA

ENSG00000151414-NEK7

Ensembl

ENST00000538004, ENSP00000444621, ENSG00000151414, ENSP00000356355, ENST00000367383, ENST00000367385, ENSP00000356353

Pharos - Targets

Q8TDX7

ZINC - Predictions - Purchasable

NEK7_HUMAN

HMDB Protein

HMDBP01432

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.675	4
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.638	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:P61224 RAP1B	2	RAP1B [azurophil granule membrane] (R-HSA-6804972) RAP1B [plasma membrane] (R-HSA-377590)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.556	3
UniProt:Q10981 FUT2	1	FUT2 [Golgi membrane] (R-HSA-2980904)	0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q9HC35 EML4	12	EML4(1-780)-ALK(1058-1620) fusion [cytosol] (R-HSA-9716119) EML4(1-569)-ALK(1078-1620) fusion [cytosol] (R-HSA-9716112) EML4(1-486)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9699918) EML4(1-223)insKMSTREKNSQV -p-7Y ALK(1059-1620) fusion [cytosol] (R-HSA-9699885) EML4(1-223)-p-7Y ALK(1059-1620) fusion [cytosol] (R-HSA-9699903) EML4(1-569)-p-7Y ALK(1078-1620) fusion [cytosol] (R-HSA-9716116) EML4(1-780)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9716113) EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion [cytosol] (R-HSA-9699813) EML4(1-223)-ALK(1059-1620) fusion [cytosol] (R-HSA-9699862) EML4(1-486)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699812) p-S,T-EML4 [cytosol] (R-HSA-9648096) EML4 [cytosol] (R-HSA-9647741)	0.508	2
UniProt:P00558 PGK1	1	PGK1 [cytosol] (R-HSA-70483)	0.499	2

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